ArticleAmerican journal of physiology. Endocrinology and metabolism2008
Prepubertal OVX increases IGF-I expression and bone accretion in C57BL/6J mice.
Article in American journal of physiology. Endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Germ cells are hidden contributors to sex differences in vertebrate lifespan.The Journal of reproduction and development · 2026Review
- Estrogen deficiency impedes fracture healing despite eliminating the excessive absorption of the posterior callus in a semi-fixed distal tibial fracture mouse model.BMC musculoskeletal disorders · 2023Article
- The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats.Reproductive biology and endocrinology : RB&E · 2022Article
- Estrogen Receptor-α Suppresses Liver Carcinogenesis and Establishes Sex-Specific Gene Expression.Cancers · 2021Article
- P2X7 receptor regulates osteoclast function and bone loss in a mouse model of osteoporosis.Scientific reports · 2018Article
- Estrogens and Androgens in Skeletal Physiology and Pathophysiology.Physiological reviews · 2017Review
- Does the GH/IGF-1 axis contribute to skeletal sexual dimorphism? Evidence from mouse studies.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2016Review
- Sex steroid actions in male bone.Endocrine reviews · 2014Review
- In vivo evidence of IGF-I-estrogen crosstalk in mediating the cortical bone response to mechanical strain.Bone research · 2014Article
- Reduced bone turnover in mice lacking the P2Y13 receptor of ADP.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Elbow loading promotes longitudinal bone growth of the ulna and the humerus.Journal of bone and mineral metabolism · 2012Article
- Hypothalamic suppression during adolescence varies by bone envelope.Medicine and science in sports and exercise · 2011Article
- The role of GH/IGF-I-mediated mechanisms in sex differences in cortical bone size in mice.Calcified tissue international · 2011Review
- Lengthening of mouse hindlimbs with joint loading.Journal of bone and mineral metabolism · 2010Article
- Ephrin B1 regulates bone marrow stromal cell differentiation and bone formation by influencing TAZ transactivation via complex formation with NHERF1.Molecular and cellular biology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
It is generally well accepted that the pubertal surge in estrogen is responsible for the rapid bone accretion that occurs during puberty and that this effect is mediated by an estrogen-induced increase in growth hormone (GH)/insulin-like growth factor (IGF) action. To test the cause and effect relationship between estrogen and GH/IGF, we evaluated the consequence of ovariectomy (OVX) in prepubertal mice (C57BL/6J mice at 3 wk of age) on skeletal changes and the GH/IGF axis during puberty. Contrary to our expectations, OVX increased body weight (12-18%), bone mineral content (11%), bone length (4%), bone size (3%), and serum, liver, and bone IGF-I (30-50%) and decreased total body fat (18%) at 3 wk postsurgery. To determine whether estrogen is the key ovarian factor responsible for these changes, we performed a second experiment in which OVX mice were treated with placebo or estrogen implants. In addition to observing similar results compared with our first experiment, estrogen treatment partially rescued the increased body weight and bone size and completely rescued body fat and IGF-I levels. The increased bone accretion in OVX mice was due to increased bone formation rate (as determined by bone histomorphometry) and increased serum procollagen peptide. In conclusion, contrary to the known estrogen effect as an initiator of GH/IGF surge and thereby pubertal growth spurt, our findings demonstrate that loss of estrogen and/or other hormones during the prepubertal growth period effect leads to an increase in IGF-I production and bone accretion in mice.
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