ArticleNucleic acids research2008
Megasatellites: a peculiar class of giant minisatellites in genes involved in cell adhesion and pathogenicity in Candida glabrata.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Variable Tandem Glycine-Rich Repeats Contribute to Cell Death-Inducing Activity of a Glycosylphosphatidylinositol-Anchored Cell Wall Protein That Is Associated with the Pathogenicity of Sclerotinia sclerotiorum.Microbiology spectrum · 2023Article
- Article
- Comparative genomic analysis of clinicalStudies in mycology · 2021Article
- Review
- Review
- Adhesins inJournal of fungi (Basel, Switzerland) · 2018Review
- Candida glabrata Biofilms: How Far Have We Come?Journal of fungi (Basel, Switzerland) · 2017Review
- Genome-wide replication landscape of Candida glabrata.BMC biology · 2015Article
- One small step for a yeast--microevolution within macrophages renders Candida glabrata hypervirulent due to a single point mutation.PLoS pathogens · 2014Article
- Genome structure and dynamics of the yeast pathogen Candida glabrata.FEMS yeast research · 2014Review
- Candida glabrata: a review of its features and resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- Detection and characterization of megasatellites in orthologous and nonorthologous genes of 21 fungal genomes.Eukaryotic cell · 2013Article
- Heterogeneous expression of the virulence-related adhesin Epa1 between individual cells and strains of the pathogen Candida glabrata.Eukaryotic cell · 2012Article
- Candida glabrata Pwp7p and Aed1p are required for adherence to human endothelial cells.FEMS yeast research · 2011Article
- Dynamic evolution of megasatellites in yeasts.Nucleic acids research · 2010Article
- WAMI: a web server for the analysis of minisatellite maps.BMC evolutionary biology · 2010Article
- Megasatellites: a new class of large tandem repeats discovered in the pathogenic yeast Candida glabrata.Cellular and molecular life sciences : CMLS · 2010Review
- Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Minisatellites are DNA tandem repeats that are found in all sequenced genomes. In the yeast Saccharomyces cerevisiae, they are frequently encountered in genes encoding cell wall proteins. Minisatellites present in the completely sequenced genome of the pathogenic yeast Candida glabrata were similarly analyzed, and two new types of minisatellites were discovered: minisatellites that are composed of two different intermingled repeats (called compound minisatellites), and minisatellites containing unusually long repeated motifs (126-429 bp). These long repeat minisatellites may reach unusual length for such elements (up to 10 kb). Due to these peculiar properties, they have been named 'megasatellites'. They are found essentially in genes involved in cell-cell adhesion, and could therefore be involved in the ability of this opportunistic pathogen to colonize the human host. In addition to megasatellites, found in large paralogous gene families, there are 93 minisatellites with simple shorter motifs, comparable to those found in S. cerevisiae. Most of the time, these minisatellites are not conserved between C. glabrata and S. cerevisiae, although their host genes are well conserved, raising the question of an active mechanism creating minisatellites de novo in hemiascomycetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.