ArticleThe British journal of ophthalmology2009
Expression of heat shock protein 27 and alpha-crystallins in human retinoblastoma after chemoreduction.
Article in The British journal of ophthalmology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients.Journal of cancer research and clinical oncology · 2011Trial
- The protective role of HSP27 in ocular diseases.Molecular biology reports · 2022Review
- A New Inflammation-Related Risk Model for Predicting Hepatocellular Carcinoma Prognosis.BioMed research international · 2022Article
- General Structural and Functional Features of Molecular Chaperones.Advances in experimental medicine and biology · 2021Article
- Progression of the role of CRYAB in signaling pathways and cancers.OncoTargets and therapy · 2019Review
- Molecular markers of DNA damage and repair in cervical cancer patients treated with cisplatin neoadjuvant chemotherapy: an exploratory study.Cell stress & chaperones · 2017Article
- New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells.Oncotarget · 2016Article
- The small heat shock protein αA-crystallin negatively regulates pancreatic tumorigenesis.Oncotarget · 2016Article
- Phosphorylation of alphaB-crystallin in epiretinal membrane of human proliferative diabetic retinopathy.International journal of ophthalmology · 2016Article
- HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins.Cancers · 2014Article
- Molecular Insights on Post-chemotherapy Retinoblastoma by Microarray Gene Expression Analysis.Bioinformatics and biology insights · 2013Article
- Expression of heat shock protein 27 and proliferating cell nuclear antigen in human retinoblastoma.Contemporary oncology (Poznan, Poland) · 2013Article
- Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update.Archives of toxicology · 2013Review
- Pathology-dependent effects linked to small heat shock proteins expression: an update.Scientifica · 2012Review
- Downregulation of AlphaB-crystallin in Retinal Pigment Epithelial Cells Exposed to Diabetes-related StimuliIn vivo (Athens, Greece)Article
- Expression of alpha-crystallins in human sebaceous carcinoma of the eyelid.European journal of ophthalmologyArticle
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3 authors at 1 institution in 1 country.
Funding
Abstract
aimSmall heat shock proteins (sHSP) play an important role in the resistance to anticancer drugs. We examined the expression of the sHSP family, HSP27 and alpha-crystallins, in human retinoblastoma with and without preoperative chemotherapy.
methodsEighteen enucleated eyes from patients with retinoblastoma were used. Six patients had undergone chemotherapy before enucleation. Formalin-fixed, paraffin-embedded tissue sections were processed for H&E staining and examined by immunohistochemistry using anti-HSP27 and alpha-crystallins antibodies.
resultsEleven of 12 cases with no history of preoperative chemotherapy showed weakly positive or negative staining for HSP27, whereas six and five cases were strongly positive for alphaA and alphaB-crystallin, respectively. In the six cases with a history of chemotherapy, several viable retinoblastoma cells remained. Immunoreactivity for HSP27 and alphaB-crystallin was strongly detected in the cytoplasm of viable retinoblastoma cells, while alphaA-crystallin immunoreactivity was less marked. Immunoreactivity for HSP27 was significantly higher in retinoblastoma cases with preoperative chemotherapy than in those without chemotherapy (p<0.0001). In contrast, immunoreactivity for alphaA-crystallin was significantly lower in cases with chemotherapy than in cases without chemotherapy (p<0.01).
conclusionsHSP27 and alphaB-crystallin, but not alphaA-crystallin, were highly expressed in viable tumour cells after chemotherapy, suggesting that HSP27 and alphaB-crystallin may protect tumour cells from apoptotic signals produced by anticancer drugs in retinoblastoma.
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