ArticleBrain research bulletin2009
Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells.
Article in Brain research bulletin, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Evaluation of developmental toxicity of chlorpyrifos through new approach methodologies: a systematic review.Archives of toxicology · 2025Pooled it
- Persistent neurobehavioral and neurochemical anomalies in middle-aged rats after maternal diazinon exposure.Toxicology · 2022Article
- Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems.Toxicology · 2019Article
- Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.American journal of physiology. Lung cellular and molecular physiology · 2018Review
- Toxic and transcriptional responses of PC12 cells to soluble tungsten alloy surrogates.Toxicology reports · 2015Article
- Transposable element islands facilitate adaptation to novel environments in an invasive species.Nature communications · 2014Article
- Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Functional pathways altered after silencing Pnpla6 (the codifying gene of neuropathy target esterase) in mouse embryonic stem cells under differentiation.In vitro cellular & developmental biology. Animal · 2014Article
- Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus compounds paraoxon and mipafox.International journal of molecular sciences · 2014Article
- Toxicogenomic studies of human neural cells following exposure to organophosphorus chemical warfare nerve agent VX.Neurochemical research · 2013Article
- Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation.Neurotoxicology and teratology · 2012Article
- Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro.Neurotoxicology and teratology · 2012Article
- Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo.Brain research bulletin · 2011Article
- Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment.BMC genomics · 2011Article
- Article
- Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants.Brain research bulletin · 2010Article
- Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo.Brain research · 2010Article
- Benzo[a]pyrene impairs neurodifferentiation in PC12 cells.Brain research bulletin · 2009Article
- Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells.Environmental health perspectives · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Unrelated developmental neurotoxicants nevertheless converge on common functional and behavioral outcomes. We used PC12 cells, a model of neuronal development, to explore similarities and differences for organophosphate pesticides (chlorpyrifos, diazinon), an organochlorine pesticide (dieldrin) and a metal (Ni(2+)), focusing on transcriptional profiles related to differentiation into acetylcholine, dopamine and norepinephrine phenotypes. Agents were introduced at 30 microM for 24 or 72 h, treatments devoid of cytotoxicity. Using microarrays, we examined the mRNAs encoding the proteins involved in neurotransmitter biosynthesis, storage, and degradation, along with the complete panoply of receptors for each transmitter. All three pesticides evoked concordant patterns of effects on genes involved in neural growth and neurite extension, with a distinctly different pattern for Ni(2+). All four toxicants promoted differentiation into the dopamine phenotype at the expense of the acetylcholine phenotype, involving separable effects of each agent on the various gene families; however, there were major differences in the ability of each to promote or repress the norepinephrine phenotype. Chlorpyrifos and diazinon, although displaying many similarities in their transcriptional profiles, also showed major disparities in keeping with their known differences in synaptic and behavioral outcomes after neonatal exposures to these agents in vivo. Surprisingly, there were closer similarities among diazinon, dieldrin and Ni(2+) than for each agent to chlorpyrifos. Our results illustrate how cell culture systems, combined with microarray technology, can screen for developmental neurotoxicants, serving as a model for alternative approaches to the detection and characterization of the impact of exogenous chemicals on brain development.
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