ArticlePacing and clinical electrophysiology : PACE2008
Ventricular arrhythmias after left ventricular assist device implantation.
Article in Pacing and clinical electrophysiology : PACE, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- A Review of New-Onset Ventricular Arrhythmia after Left Ventricular Assist Device Implantation.Cardiology · 2022Pooled it
- Clinical implications of left ventricular assist device implantation in patients with an implantable cardioverter-defibrillator.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2014Trial
- Atrial fibrillation in continuous flow-left ventricular assist device (CF-LVAD) patients: impact on pathophysiology.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Review
- Drug therapy and catheter ablation for management of arrhythmias in continuous flow left ventricular assist device's patients: a Clinical Consensus Statement of the European Heart Rhythm Association and the Heart Failure Association of the ESC.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Design and characteristics of the prophylactic intra-operative ventricular arrhythmia ablation in high-risk LVAD candidates (PIVATAL) trial.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023Article
- Combined mechanical circulatory support for ventricular fibrillation in left ventricular assist device patient.ESC heart failure · 2022Article
- Amiodarone Use and All-Cause Mortality in Patients With a Continuous-Flow Left Ventricular Assist Device.Journal of the American Heart Association · 2022Article
- Reciprocal interferences of the left ventricular assist device and the aortic valve competence.Frontiers in cardiovascular medicine · 2022Review
- Surface mapping demonstrates compatibility of implantable loop monitor with a continuous-flow left ventricular assist device.ESC heart failure · 2021Article
- Ablation therapy for ventricular arrhythmias in patients with LVAD: Multiple faces of an electrophysiological challenge.Journal of arrhythmia · 2021Review
- Ineffective implantable cardioverter-defibrillator shocks among patients on continuous left ventricular assist device support: Clinical characteristics and management.Heart rhythm O2 · 2020Article
- Ventricular arrhythmias in patients with biventricular assist devices.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2020Article
- Atrial Fibrillation Is Associated with Recurrent Ventricular Arrhythmias After LVAD Implant: Incidence and Impact in a Consecutive Series.Journal of cardiovascular translational research · 2020Article
- Benefits of Neurohormonal Therapy in Patients With Continuous-Flow Left Ventricular Assist Devices.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
- Cryoablation during left ventricular assist device implantation: A case report: Ignoramus et Ignorabimus, Sapere Aude.JTCVS techniques · 2020Article
- Heart failure as a substrate and trigger for ventricular tachycardia.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2019Review
- ICD shocks in LVAD patients are not associated with increased subsequent mortality risk.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2019Article
- Ventricular Arrhythmias in Patients With Left Ventricular Assist Device (LVAD).Current treatment options in cardiovascular medicine · 2019Review
- Hurdles to Cardioprotection in the Critically Ill.International journal of molecular sciences · 2019Review
- Windkessel model of hemodynamic state supported by a pulsatile ventricular assist device in premature ventricle contraction.Biomedical engineering online · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLeft ventricular assist devices (LVADs) have been used as a bridge to cardiac transplantation and as destination therapy in patients with advanced heart failure. The period after LVAD support is associated with ventricular arrhythmias (VAs) despite ventricular unloading and such VAs can have a detrimental effect on survival. Despite the increasing use of LVAD, little is known regarding post-LVAD VAs at the molecular level and in vivo.
methodsForty-two patients who received LVAD over a 24-month period were evaluated and grouped on the basis of the presence or absence of VAs during LVAD support. We completed a comparative microarray analyses between six patients who developed ventricular tachycardia (VT) or ventricular fibrillation (VF) after LVAD support and six patients who did not develop VAs after LVAD.
resultsVAs occurred in 15 patients (35.7%) during LVAD support at a median post-LVAD day of 25.2. VAs were strongly associated with nonusage of a beta-blocker post-LVAD (odds ratio of 7.04, P-value = 0.001). Analysis of a subset of patients who had VT or VF after LVAD placement showed a decrease in the expression of connexin 43 (0.48 +/- 0.07), Na+/K+-ATPase (0.60 +/- 0.05), and voltage-gated K+ channel Kv4.3 (0.42 +/- 0.04), and an increase in Na+/Ca2+ exchanger (2.2 +/- 0.4) and the structural genes: Titin (2.1 +/- 0.2), laminin (1.7 +/- 0.4), calsequestrin (1.8 +/- 0.5), skeletal muscle isoform of troponin T (5.1 +/- 0.9), and skeletal muscle isoform of troponin I (3.9 +/- 0.7).
conclusionAfter LVAD, the increased risk of VAs is strongly associated with nonusage of beta-blocker postoperatively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.