ReviewFEMS microbiology reviews2008
Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi.
Review in FEMS microbiology reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 212 citations in OpenAlex.
- A co-evolved peptide-GPCR system senses host entry to drive fungal infection.Nature communications · 2026Article
- Mating-type locus structure affects gene expression in unidirectional mating-type switching fungi.G3 (Bethesda, Md.) · 2026Article
- Lineage-specific diversity of pheromone response pathway genes is independent of mating strategy in Ceratocystidaceae.BMC genomics · 2026Article
- Article
- Sequence constraints predispose Class D GPCRs to follow an atypical activation mechanism.bioRxiv : the preprint server for biology · 2026Article
- A yeast mating platform for multiplex screening of fungal GPCR-ligand interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genomic Insights into the Molecular Basis of Broad Host Adaptability of the Entomopathogenic FungusJournal of fungi (Basel, Switzerland) · 2025Article
- Chromosome-Level Genome Announcement of the MonokaryoticJournal of fungi (Basel, Switzerland) · 2025Article
- The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis.PLoS pathogens · 2025Article
- Signaling Pathways Regulating Dimorphism in Medically Relevant Fungal Species.Pathogens (Basel, Switzerland) · 2025Review
- Fungal Stress Responses and the Importance of GPCRs.Journal of fungi (Basel, Switzerland) · 2025Review
- Conserved signaling modules regulate filamentous growth in fungi: a model for eukaryotic cell differentiation.Genetics · 2024Review
- The decision for or against mycoparasitic attack by Trichoderma spp. is taken already at a distance in a prey-specific manner and benefits plant-beneficial interactions.Fungal biology and biotechnology · 2024Article
- Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway.Cellular and molecular life sciences : CMLS · 2024Article
- Conserved perception of host and non-host signals via the a-pheromone receptor Ste3 inFrontiers in fungal biology · 2024Article
- Cysteine facilitates the lignocellulolytic response of Trichoderma guizhouense NJAU4742 by indirectly up-regulating membrane sugar transporters.Biotechnology for biofuels and bioproducts · 2023Article
- Lessons on fruiting body morphogenesis from genomes and transcriptomes ofStudies in mycology · 2023Article
- Developing novel antifungals: lessons from G protein-coupled receptors.Trends in pharmacological sciences · 2023Review
- Genome-Wide Identification of G Protein-Coupled Receptors in Ciliated Eukaryotes.International journal of molecular sciences · 2023Article
- Genome-wide identification of the opsin protein inFrontiers in microbiology · 2023Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
G protein-coupled receptors (GPCRs) represent the largest family of transmembrane receptors and are responsible for transducing extracellular signals into intracellular responses that involve complex intracellular-signaling networks. This review highlights recent research advances in fungal GPCRs, including classification, extracellular sensing, and G protein-signaling regulation. The involvement of GPCRs in pheromone and nutrient sensing has been studied extensively over the past decade. Following recent advances in fungal genome sequencing projects, a panoply of GPCR candidates has been revealed and some have been documented to play key roles sensing diverse extracellular signals, such as pheromones, sugars, amino acids, nitrogen sources, and even photons. Identification and deorphanization of additional putative GPCRs may require the development of new research tools. Here, we compare research on GPCRs in fungi with information derived from mammalian systems to provide a useful road map on how to better understand ligand-GPCR-G protein interactions in general. We also emphasize the utility of yeast as a discovery tool for systemic studies of GPCRs from other organisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.