ArticleInsect molecular biology2008
Semliki Forest virus strongly reduces mosquito host defence signaling.
Article in Insect molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- The JAK-STAT pathway in invertebrates: An emerging battleground for host‒virus warfare.Insect science · 2026Review
- Advances in antiviral strategies targeting mosquito-borne viruses: cellular, viral, and immune-related approaches.Virology journal · 2025Review
- The Japanese encephalitis virus NS1' protein facilitates virus infection in mosquitoes.PLoS neglected tropical diseases · 2025Article
- Capsid protein mediated evasion of IRAK1-dependent signalling is essential to Sindbis virus neuroinvasion and virulence in mice.Emerging microbes & infections · 2024Article
- Response of the mosquito immune system and symbiotic bacteria to pathogen infection.Parasites & vectors · 2024Review
- Mosquito transgenerational antiviral immunity is mediated by vertical transfer of virus DNA sequences and RNAi.iScience · 2024Article
- Rift Valley Fever Virus Primes Immune Responses inPathogens (Basel, Switzerland) · 2023Article
- Impact of CHIKV Replication on the Global Proteome ofProteomes · 2022Article
- Perturbation of Alphavirus and Flavivirus Infectivity by Components of the Bacterial Cell Wall.Journal of virology · 2022Article
- Effects of Guangzhou seasonal climate change on the development of Aedes albopictus and its susceptibility to DENV-2.PloS one · 2022Article
- Inhibition of defensin A and cecropin A responses to dengue virus 1 infection in Aedes aegypti.Biomedica : revista del Instituto Nacional de Salud · 2021Article
- Imd pathway-specific immune assays reveal NF-κB stimulation by viral RNA PAMPs in Aedes aegypti Aag2 cells.PLoS neglected tropical diseases · 2021Article
- Vector Competence for DENV-2 AmongFrontiers in cellular and infection microbiology · 2021Article
- Effect of Oral Infection of Mayaro Virus on Fitness Correlates and Expression of Immune Related Genes inViruses · 2020Article
- Transcriptome analysis of responses to bluetongue virus infection in Aedes albopictus cells.BMC microbiology · 2019Article
- RNASeq Analysis ofViruses · 2019Article
- Interaction of RNA viruses of the natural virome with the African malaria vector, Anopheles coluzzii.Scientific reports · 2019Article
- Mosquito antiviral defense mechanisms: a delicate balance between innate immunity and persistent viral infection.Parasites & vectors · 2019Review
- Induction and Suppression of NF-κB Signalling by a DNA Virus ofJournal of virology · 2019Article
- Arboviruses and the Challenge to Establish Systemic and Persistent Infections in Competent Mosquito Vectors: The Interaction With the RNAi Mechanism.Frontiers in physiology · 2019Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The Alphavirus genus within the Togaviridae family contains several important mosquito-borne arboviruses. Other than the antiviral activity of RNAi, relatively little is known about alphavirus interactions with insect cell defences. Here we show that Semliki Forest virus (SFV) infection of Aedes albopictus-derived U4.4 mosquito cells reduces cellular gene expression. Activation prior to SFV infection of pathways involving STAT/IMD, but not Toll signaling reduced subsequent virus gene expression and RNA levels. These pathways are therefore not only able to mediate protective responses against bacteria but also arboviruses. However, SFV infection of mosquito cells did not result in activation of any of these pathways and suppressed their subsequent activation by other stimuli.
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