ArticleThe Journal of pathology2008
A critical role for TRAIL in resolution of granulomatous experimental autoimmune thyroiditis.
Article in The Journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Dichotomy in duration and severity of acute inflammatory responses in humans arising from differentially expressed proresolution pathways.Proceedings of the National Academy of Sciences of the United States of America · 2010Trial
- Case Report: Anti-TNF-α therapy-associated destructive thyroiditis and unmasking of latent amyloid A amyloidosis in rheumatoid arthritis.Frontiers in immunology · 2026Article
- Apoptotic cell death in disease-Current understanding of the NCCD 2023.Cell death and differentiation · 2023Review
- A Potential Role for Green Tea as a Radiation Sensitizer for Prostate Cancer.Pathology oncology research : POR · 2019Article
- Blueberry as a Potential Radiosensitizer for Treating Cervical Cancer.Pathology oncology research : POR · 2019Article
- IL-33 notably inhibits the growth of colon cancer cells.Oncology letters · 2018Article
- IL-33 acts as a foe to MIA PaCa-2 pancreatic cancer.Medical oncology (Northwood, London, England) · 2017Article
- Trichomonas vaginalis: a possible foe to prostate cancer.Medical oncology (Northwood, London, England) · 2016Article
- Resolution of inflammation: a new therapeutic frontier.Nature reviews. Drug discovery · 2016Review
- Immune disorders in Hashimoto's thyroiditis: what do we know so far?Journal of immunology research · 2015Review
- Switching off key signaling survival molecules to switch on the resolution of inflammation.Mediators of inflammation · 2014Review
- The resolution of inflammation.Nature reviews. Immunology · 2013Review
- Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis.Cancer science · 2012Article
- TGF-β promotes proliferation of thyroid epithelial cells in IFN-γ(-/-) mice by down-regulation of p21 and p27 via AKT pathway.The American journal of pathology · 2012Article
- Effect of transgenic overexpression of FLIP on lymphocytes on development and resolution of experimental autoimmune thyroiditis.The American journal of pathology · 2011Article
- Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Comparison of sensitivity of Th1, Th2, and Th17 cells to Fas-mediated apoptosis.Journal of leukocyte biology · 2010Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by mouse thyroglobulin (MTG)-sensitized splenocytes activated in vitro with MTG and IL-12. Thyroid lesions reach maximal severity 20 days after cell transfer, and usually resolve or progress to fibrosis by day 60 depending on the extent of thyroid damage at day 20. Our previous studies indicated that neutralization of TNF-alpha or FasL had no effect on G-EAT induction, but neutralization of TNF-alpha promoted, while neutralization of FasL inhibited, G-EAT resolution. TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily. This study was undertaken to define the role of endogenous TRAIL in G-EAT development and/or resolution. Neutralization of endogenous TRAIL had little effect on G-EAT induction, but significantly inhibited G-EAT resolution and increased thyroid fibrosis. This correlated with higher expression of pro-inflammatory cytokines and preferential expression of the pro-apoptotic molecule TRAIL, and anti-apoptotic molecules FLIP and Bcl-xL on inflammatory cells in thyroids of anti-TRAIL-treated recipients. The results suggest that endogenous TRAIL is not required for G-EAT development in recipients, but is critical for G-EAT resolution. Endogenous TRAIL might promote resolution, at least in part, through modulation of the balance between pro- and anti-inflammatory cytokines, and the expression pattern of pro- and anti-apoptotic molecules of thyroid epithelial cells (TECs) and inflammatory cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.