ArticleGlycoconjugate journal2009
Functional characterization of an eosinophil-specific galectin, ovine galectin-14.
Article in Glycoconjugate journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Abnormal Galectin Signaling in the Pathomechanisms of Placental Dysfunction in Gestational Diabetes Mellitus.International journal of molecular sciences · 2026Review
- Deciphering theBiomolecules · 2025Review
- Role of Galectin-1 in the Pathogenesis of Melanoma.Journal of cancer science and clinical therapeutics · 2025Article
- Evaluation of the Role of Galectins in Parasite Immunity.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The interaction of host and nematode galectins influences the outcome of gastrointestinal nematode infections.Parasitology · 2021Review
- Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation.Current allergy and asthma reports · 2019Review
- Article
- The roles of galectins in parasitic infections.Acta tropica · 2018Review
- Regulation of Eosinophil Recruitment and Activation by Galectins in Allergic Asthma.Frontiers in medicine · 2017Review
- Time-Course Study of the Transcriptome of Peripheral Blood Mononuclear Cells (PBMCs) from Sheep Infected with Fasciola hepatica.PloS one · 2016Article
- Towards molecular mechanisms regulating the expression of galectins in cancer cells under microenvironmental stress conditions.Cellular and molecular life sciences : CMLS · 2015Review
- Transcriptional analysis identifies key genes involved in metabolism, fibrosis/tissue repair and the immune response against Fasciola hepatica in sheep liver.Parasites & vectors · 2015Article
- Enhanced epimerization of glycosylated amino acids during solid-phase peptide synthesis.Journal of the American Chemical Society · 2012Article
- The effect of plant tissue and vaccine formulation on the oral immunogenicity of a model plant-made antigen in sheep.PloS one · 2012Article
- Galectins: guardians of eutherian pregnancy at the maternal-fetal interface.Trends in endocrinology and metabolism: TEM · 2012Review
- Glycan microarrays for decoding the glycome.Annual review of biochemistry · 2011Review
- Eosinophil-mediated tissue inflammatory responses in helminth infection.The Korean journal of parasitology · 2009Review
- Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation.Nature reviews. Immunology · 2009Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Across mammalian species, human galectin-10 and ovine galectin-14 are unique in their expression in eosinophils and their release into lung and gastrointestinal tissues following allergen or parasite challenge. Recombinant galectin-14 is active in carbohydrate binding assays and has been used in this study to unravel the function of this major eosinophil constituent. In vitro cultures revealed that galectin-14 is spontaneously released by eosinophils isolated from allergen-stimulated mammary gland lavage, but not by resting peripheral blood eosinophils. Galectin-14 secretion from peripheral blood eosinophils can be induced by the same stimuli that induce eosinophil degranulation. Flow cytometric analysis showed that recombinant galectin-14 can bind in vitro to eosinophils, neutrophils and activated lymphocytes. Glycan array screening indicated that galectin-14 recognizes terminal N-acetyllactosamine residues which can be modified with alpha1-2-fucosylation and, uniquely for a galectin, prefers alpha2- over alpha2-sialylation. Galectin-14 showed the greatest affinity for lacto-N-neotetraose, an immunomodulatory oligosaccharide expressed by helminths. Galectin-14 binds specifically to laminin in vitro, and to mucus and mucus producing cells on lung and intestinal tissue sections. In vivo, galectin-14 is abundantly present in mucus scrapings collected from either lungs or gastrointestinal tract following allergen or parasite challenge, respectively. These results suggest that in vivo secretion of eosinophil galectins may be specifically induced at epithelial surfaces after recruitment of eosinophils by allergic stimuli, and that eosinophil galectins may be involved in promoting adhesion and changing mucus properties during parasite infection and allergies.
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Registered trials
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