ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2008
In vitro study of haematoporphyrin monomethyl ether-mediated sonodynamic effects on C6 glioma cells.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Sonodynamic therapy for adult-type diffuse gliomas: past, present, and future.Journal of neuro-oncology · 2024Pooled it
- Ultrasound-responsive nanoparticles for imaging and therapy of brain tumors.Materials today. Bio · 2025Review
- Preparation of LaFrontiers in bioengineering and biotechnology · 2025Article
- In Vitro Sonodynamic Therapy Using a High Throughput 3D Glioblastoma Spheroid Model with 5-ALA and TMZ Sonosensitizers.Advanced healthcare materials · 2024Article
- Reactive oxidative species (ROS)-based nanomedicine for BBB crossing and glioma treatment: current status and future directions.Frontiers in immunology · 2023Review
- Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives.Military Medical Research · 2022Review
- Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies.Acta pharmaceutica Sinica. B · 2021Review
- Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Sonodynamic Therapy for the Treatment of Intracranial Gliomas.Journal of clinical medicine · 2021Review
- In vitro ultrasound experiments: Standing wave and multiple reflections influence on the outcome.Ultrasonics · 2017Article
- Antiproliferative and Apoptosis-inducing Effect of exo-Protoporphyrin IX based Sonodynamic Therapy on Human Oral Squamous Cell Carcinoma.Scientific reports · 2017Article
- Effect of photodynamic therapy combined with torasemide on the expression of matrix metalloproteinase 2 and sodium-potassium-chloride cotransporter 1 in rat peritumoral edema and glioma.Oncology letters · 2016Article
- A new sensitizer DVDMS combined with multiple focused ultrasound treatments: an effective antitumor strategy.Scientific reports · 2015Article
- Study of the mechanism of sonodynamic therapy in a rat glioma model.OncoTargets and therapy · 2014Article
- Apoptosis of U937 cells induced by hematoporphyrin monomethyl ether-mediated sonodynamic action.Cancer biotherapy & radiopharmaceuticals · 2013Article
- In vitro study of low intensity ultrasound combined with different doses of PDT: Effects on C6 glioma cells.Oncology letters · 2013Article
- Article
- Use of a novel sonosensitizer in sonodynamic therapy of U251 glioma cells in vitro.Experimental and therapeutic medicine · 2012Article
- Spectroscopic investigation on the synergistic effects of ultrasound and dioxopromethazine hydrochloride on protein.Journal of fluorescence · 2011Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo study the cytotoxicity induced by haematoporphyrin monomethyl ether (HMME)-mediated sonodynamic therapy (SDT) on C6 glioma cells.
methodsThe potent photosensitizer HMME was used as the sensitizer. Rat C6 glioma cells were incubated with HMME (10 microg/mL) in the dark for 2 h and then subjected to ultrasound treatment at 1.0 MHz and 0.5 W/cm2 for 2 min. The growth inhibition rate at different time points after SDT was determined by MTT assay. The apoptotic rate and cell circle profiles were examined with flow cytometry. Fine structures were observed with transmission electron microscope (TEM). The sonodynamic effect on the glioma cells was also studied in the absence or presence of various reactive oxygen species (ROS) scavengers.
resultsThe growth inhibition rate of C6 glioma cells after SDT significantly increased. SDT also increased the apoptosis and proliferation rate (APR). TEM examination showed the morphological features of apoptosis or necrosis. The addition of NaN(3) showed a strong protective effect again SDT.
conclusionsOur data indicated that SDT could kill C6 glioma cells in vitro and possibility through induction of apoptosis and necrosis. Singlet oxygen ((1)O2) may play an important role in SDT.
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Registered trials
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