ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2008
Olfactory discrimination of aliphatic odorants at 1 ppm: too easy for CD-1 mice to show odor structure-activity relationships?
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Laminar architecture of a decision circuit in the mouse orbitofrontal cortex.Nature communications · 2026Article
- The Laminar Organization of a Decision Circuit in Orbitofrontal Cortex is Agnostic to the Variable Encoding Scheme.bioRxiv : the preprint server for biology · 2026Article
- Distinct odorant receptor response patterns to aliphatic odorants in freely behaving mice.Chemical senses · 2025Article
- Vasopressin receptor 1a, oxytocin receptor, and oxytocin knockout male and female mice display normal perceptual abilities towards non-social odorants.Hormones and behavior · 2023Article
- Rodent responses to volatile compounds provide insights into the function of floral scent in mammal-pollinated plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Olfactory Detection Thresholds for Primary Aliphatic Alcohols in Mice.Chemical senses · 2020Article
- Interaction between age and perceptual similarity in olfactory discrimination learning in F344 rats: relationships with spatial learning.Neurobiology of aging · 2017Article
- An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning.Scientific reports · 2015Article
- Characterizing olfactory perceptual similarity using carbon chain discrimination in Fischer 344 rats.Chemical senses · 2014Article
- Are mammal olfactory signals hiding right under our noses?Die Naturwissenschaften · 2013Review
- Olfactory sensitivity and odor structure-activity relationships for aliphatic carboxylic acids in CD-1 mice.PloS one · 2012Article
- Olfactory and visuospatial learning and memory performance in two strains of Alzheimer's disease model mice--a longitudinal study.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using an operant conditioning paradigm we tested the ability of CD-1 mice to discriminate between 25 odorants comprising members of five homologous series of aliphatic odorants (C4-C8) presented at a gas phase concentration of 1 ppm. We found (a) that all mice significantly discriminated between all 50 stimulus pairs that involved odorants sharing the same functional group, but differing in carbon chain length, as well as between all 50 stimulus pairs that involved odorants sharing the same carbon chain length but differing in functional group, (b) a significant negative correlation between discrimination performance and structural similarity of odorants in terms of differences in carbon chain length with the acetic esters and the 2-ketones, but not with the 1-alcohols, n-aldehydes, and n-carboxylic acids tested, and (c) that odorant pairs differing in functional group were significantly better discriminated than odorant pairs differing in carbon chain length. These findings demonstrate that CD-1 mice have excellent discrimination ability for structurally related aliphatic odorants, that correlations between discrimination performance and structural similarity of odorants are odorant class-specific rather than a general phenomenon, and that both carbon chain length and type of functional group play an important role for odor quality coding in mice.
Indexed as
Identifiers
18810459What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.