ArticleIndian journal of pediatrics2008
Gene polymorphisms of IL-6(-174) G/C and IL-1Ra VNTR in asthmatic children.
Article in Indian journal of pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Effects ofFrontiers in genetics · 2022Pooled it
- Association between polymorphism of interleukin-1 beta and interleukin-1 receptor antagonist gene and asthma risk: a meta-analysis.TheScientificWorldJournal · 2015Pooled it
- Article
- Association between interleukin-6-174G/C gene polymorphism and asthma severity: exploring the role of total serum IgE, blood eosinophils, and FeNO as markers of type 2 inflammation.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024Article
- Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics.Cytokine & growth factor reviews · 2021Review
- Expression of suppressor of cytokine signaling 3 (SOCS3) and interleukin-6 (-174-G/C) polymorphism in atopic conditions.PloS one · 2019Article
- Interleukin 6 SNP rs1800797 associates with the risk of adult-onset asthma.Genes and immunity · 2016Article
- Interleukin-6 gene -174G/C polymorphism and bronchial asthma risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Interleukin-18 -607C/A gene polymorphism in Egyptian asthmatic children.Molecular diagnosis & therapy · 2014Article
- IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.Nature medicine · 2012Article
- Cytokine gene polymorphism and asthma susceptibility, progress and control level.Molecular biology reports · 2012Article
- Importance of cytokines in murine allergic airway disease and human asthma.Journal of immunology (Baltimore, Md. : 1950) · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo check for the association of genetic polymorphisms of IL-6-(-174)G/C and IL-1RaVNTR with the susceptibility and severity of asthma in Egyptian children.
methodsSubjects included 69 asthmatic children and 98 healthy unrelated controls from the Nile Delta of Egypt. Cases consisted of 20 males and 49 females with an age mean +/- SD is 7.5 +/- 2.1 ranging between 2-13 years. DNA amplification using PCR with sequence-specific primers was done for detection of promotor single nucleotide polymorphism of IL-6 gene as well as intron 2 VNTR of IL-1Ra gene. Frequency of case-genotypes or alleles were compared to controls using Fisher exact test and Odds ratio.
resultsCases showed significant higher frequency of the genotypes: IL-6-174 GG (P<0.05, OR=3.2, 95% CI=1.09-10) that was evident mainly in the uncontrolled asthma subgroup indicative of the possibility of being a severity genotype. All cases as well as case-subgroups showed high significant frequency of IL-1Ra A1A1 (p<0.0001, OR=1.5, 95% CI=1.3-1.8). This may be considered a susceptibility genotype. Cases have also shown significant lower frequency of IL-6(-174) GC and IL-1Ra A1A2 genotypes (P<0.001 and P<0.0001 respectively).
conclusionIL-6 and IL-1Ra polymorphisms can be considered genetic markers for bronchial asthma susceptibility and/or severity among Egyptian children. This may have a potential impact on family counseling and management.
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