ArticlePloS one2008
Herpes-virus infection in patients with Langerhans cell histiocytosis: a case-controlled sero-epidemiological study, and in situ analysis.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Predictors of Epstein-Barr virus serostatus and implications for vaccine policy: A systematic review of the literature.Journal of global health · 2020Pooled it
- Merkel cell polyomavirus and Langerhans cell neoplasm.Cell communication and signaling : CCS · 2018Pooled it
- IgA nephropathy: a novel pathway in immunopathogenesis dependent on the timing of Epstein-Barr virus infection.Frontiers in immunology · 2026Review
- Childhood Langerhans cell histiocytosis hematological involvement: severity associated with BRAFV600E loads.Blood · 2025Article
- Exploration of treatment in childhood Langerhans cell histiocytosis based on inflammatory and malignant symptoms: a pilot study.Orphanet journal of rare diseases · 2024Article
- Epstein-Barr Virus-Associated Langerhans Cell Histiocytosis of the Thyroid Gland.Head and neck pathology · 2021Article
- Childhood Langerhans cell histiocytosis with severe lung involvement: a nationwide cohort study.Orphanet journal of rare diseases · 2020Article
- A mutation in POLR3E impairs antiviral immune response and RNA polymerase III.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Lack of evidence for the involvement of Merkel cell polyomavirus in pulmonary Langerhans cell histiocytosis.ERJ open research · 2020Article
- Multistaining Optimization for Epstein-Barr Virus-Encoded RNA In Situ Hybridization and Immunohistochemistry of Formalin-Fixed Paraffin-Embedded Tissues Using an Automated Immunostainer.Journal of pathology and translational medicine · 2019Article
- Clinicopathological and Immunohistochemical Study of Head and Neck Langerhans Cell Histiocytosis from Latin America.Head and neck pathology · 2018Article
- How I manage pulmonary Langerhans cell histiocytosis.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- Article
- Tertiary lymphoid structures are confined to patients presenting with unifocal Langerhans Cell Histiocytosis.Oncoimmunology · 2016Article
- Cytomegalovirus and Langerhans Cell Histiocytosis: Is There a Link?Iranian journal of pediatrics · 2016Article
- Detection of Epstein-Barr Virus DNA in Langerhans Cell Histiocytosis.Jundishapur journal of microbiology · 2015Article
- Cell(s) of Origin of Langerhans Cell Histiocytosis.Hematology/oncology clinics of North America · 2015Review
- Langerhans Cell Hyperplasia From Molluscum Contagiosum.The American Journal of dermatopathology · 2015Article
- Progress in understanding the pathogenesis of Langerhans cell histiocytosis: back to Histiocytosis X?British journal of haematology · 2015Review
- Eosinophilic granuloma/Langerhans cell histiocytosis: Pediatric neurosurgery update.Surgical neurology international · 2015Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundLangerhans cell histiocytosis (LCH) is a rare disease that affects mainly young children, and which features granulomas containing Langerhans-type dendritic cells. The role of several human herpesviruses (HHV) in the pathogenesis of LCH was suggested by numerous reports but remains debated. Epstein-barr virus (EBV, HHV-4), & Cytomegalovirus (CMV, HHV-5) can infect Langerhans cells, and EBV, CMV and HHV-6 have been proposed to be associated with LCH based on the detection of these viruses in clinical samples. METHODOLOGY: We have investigated the prevalence of EBV, CMV and HHV-6 infection, the characters of antibody response and the plasma viral load in a cohort of 83 patients and 236 age-matched controls, and the presence and cellular localization of the viruses in LCH tissue samples from 19 patients. PRINCIPAL
findingsThe results show that prevalence, serological titers, and viral load for EBV, CMV and HHV-6 did not differ between patients and controls. EBV was found by PCR in tumoral sample from 3/19 patients, however, EBV small RNAs EBERs -when positive-, were detected by in situ double staining in bystander B CD20+ CD79a+ lymphocytes and not in CD1a+ LC. HHV-6 genome was detected in the biopsies of 5/19 patients with low copy number and viral Ag could not be detected in biopsies. CMV was not detected by PCR in this series. CONCLUSIONS/SIGNIFICANCE: Therefore, our findings do not support the hypothesis of a role of EBV, CMV, or HHV-6 in the pathogenesis of LCH, and indicate that the frequent detection of Epstein-barr virus (EBV) in Langerhans cell histiocytosis is accounted for by the infection of bystander B lymphocytes in LCH granuloma. The latter observation can be attributed to the immunosuppressive micro environment found in LCH granuloma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.