ArticleAntimicrobial agents and chemotherapy2008
First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of colistin resistance in clinical isolates ofFrontiers in microbiology · 2024Pooled it
- Beyond the Spotlight:Antibiotics (Basel, Switzerland) · 2025Review
- Epidemiology of β-Lactamase-Producing Pathogens.Clinical microbiology reviews · 2020Review
- Colonization of long-term care facility residents in three Italian Provinces by multidrug-resistant bacteria.Antimicrobial resistance and infection control · 2018Article
- Infections Caused by Antimicrobial Drug-Resistant Saprophytic Gram-Negative Bacteria in the Environment.Frontiers in medicine · 2017Article
- Tn6249, a new Tn6162 transposon derivative carrying a double-integron platform and involved with acquisition of the blaVIM-1 metallo-β-lactamase gene in Pseudomonas aeruginosa.Antimicrobial agents and chemotherapy · 2015Article
- Sequence types 235, 111, and 132 predominate among multidrug-resistant pseudomonas aeruginosa clinical isolates in Croatia.Antimicrobial agents and chemotherapy · 2014Article
- An outbreak of extremely drug-resistant Pseudomonas aeruginosa in a tertiary care pediatric hospital in Italy.BMC infectious diseases · 2014Article
- IMP-33, a New IMP variant detected in Pseudomonas aeruginosa from Sicily.Antimicrobial agents and chemotherapy · 2013Article
- Carbapenemase-producing Pseudomonas aeruginosa from central Greece: molecular epidemiology and genetic analysis of class I integrons.BMC infectious diseases · 2013Article
- VIM-2-producing multidrug-resistant Pseudomonas aeruginosa ST175 clone, Spain.Emerging infectious diseases · 2012Article
- Infrequent finding of metallo-β-lactamase VIM-2 in carbapenem-resistant Pseudomonas aeruginosa strains from Croatia.Antimicrobial agents and chemotherapy · 2012Article
- Overexpression of AmpC and efflux pumps in Pseudomonas aeruginosa isolates from bloodstream infections: prevalence and impact on resistance in a Spanish multicenter study.Antimicrobial agents and chemotherapy · 2011Article
- Regional spread of Pseudomonas aeruginosa ST357 producing IMP-7 metallo-β-lactamase in Central Europe.Journal of clinical microbiology · 2011Article
- Purification and biochemical characterization of IMP-13 metallo-beta-lactamase.Antimicrobial agents and chemotherapy · 2011Article
- Intercontinental dissemination of IMP-13-producing Pseudomonas aeruginosa belonging in sequence type 621.Journal of clinical microbiology · 2010Article
- Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding.Antimicrobial agents and chemotherapy · 2010Article
- First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital.Antimicrobial agents and chemotherapy · 2010Article
- Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains.Antimicrobial agents and chemotherapy · 2010Article
- Bench-to-bedside review: The role of beta-lactamases in antibiotic-resistant Gram-negative infections.Critical care (London, England) · 2010Review
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Authors and funding
12 authors.
Funding
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Abstract
Metallo-beta-lactamases (MBLs) can confer resistance to most beta-lactams, including carbapenems. Their emergence in gram-negative pathogens is a matter of major concern. Italy was the first European country to report the presence of acquired MBLs in gram-negative pathogens and is one of the countries where MBL producers have been detected repeatedly. Here, we present the results of the first Italian nationwide survey of acquired MBLs in gram-negative pathogens. Of 14,812 consecutive nonreplicate clinical isolates (12,245 Enterobacteriaceae isolates and 2,567 gram-negative nonfermenters) screened for reduced carbapenem susceptibility during a 4-month period (September to December 2004), 30 isolates (28 Pseudomonas aeruginosa isolates, 1 Pseudomonas putida isolate, and 1 Enterobacter cloacae isolate) carried acquired MBL determinants. MBL producers were detected in 10 of 12 cities, with a predominance of VIM-type enzymes over IMP-type enzymes (4:1). Although having an overall low prevalence (1.3%) and significant geographical differences, MBL-producing P. aeruginosa strains appeared to be widespread in Italy, with a notable diversity of clones, enzymes, and integrons carrying MBL gene cassettes.
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