Evidence map›Paper›PMID 18809944›Full record

ArticleAntimicrobial agents and chemotherapy2008

Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method.

Luis Ostrosky-Zeichner, John H Rex, Michael A Pfaller, Daniel J Diekema, Barbara D Alexander, David Andes, Steven D Brown, Vishnu Chaturvedi, Mahmoud A Ghannoum, Cindy C Knapp and 2 more

Abstract readComparative Study
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Luis Ostrosky-ZeichnerUniversity of Texas Medical School at Houston, Texas 77030, USA. Luis.Ostrosky-Zeichner@uth.tmc.edu
John H Rex
Michael A Pfaller
Daniel J Diekema
Barbara D Alexander
David Andes
Steven D Brown
Vishnu Chaturvedi
Mahmoud A Ghannoum
Cindy C Knapp
Daniel J Sheehan
Thomas J Walsh

Funding

Treatment of Infections in Immunocompromised Children with Cancer, HematopoieticZ01SC006830 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI WALSH, THOMAS J. · 1996 to 2008
$5.8M
Treatment of Infections in Immunocompromised ChildrenZIASC006830 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI WALSH, THOMAS J. · 2009 to 2009
$2.4M
6 · The paper itself

Abstract

We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.

Indexed as

AnimalsAntifungal AgentsCandidaCandidiasisDatabases, FactualFluconazoleHumansMicrobial Sensitivity TestsModels, BiologicalTime FactorsAntifungal AgentsFluconazole

Identifiers

PMID18809944
PMCPMC2573146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.