ArticleAntimicrobial agents and chemotherapy2008
High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 1 of them a synthesis that pooled it.
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40 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Extended Spectrum Beta-Lactamase-Producing Bacterial Clones in West Africa: A Systematic Review and Meta-Analysis from a One Health Perspective.Scientific reports · 2025Pooled it
- Epidemiology and Mechanism of Drug Resistance of Multidrug-Resistant Klebsiella Pneumoniae Isolated from Patients with Urinary Tract Infection in Beijing Teaching Hospital, China.Infection and drug resistance · 2025Article
- Prevalence of plasmid-mediated quinolone resistance genes in extended-spectrum beta-lactamase producingHeliyon · 2024Article
- Antibiotic Resistance of Bacteria Isolated from Clinical Samples and Organs of Rescued Loggerhead Sea Turtles (Animals : an open access journal from MDPI · 2024Article
- Molecular detection of genes encoding resistance to tetracycline and quinolones amongIranian journal of microbiology · 2023Article
- Comparative Studies of Antimicrobial Resistance inFoods (Basel, Switzerland) · 2023Article
- Molecular genetic testing does not improve the detection of fluoroquinolone resistance before transrectal prostate biopsy.Prostate international · 2022Article
- Plasmid-Mediated Fluoroquinolone Resistance inJournal of laboratory physicians · 2022Article
- Characterization of plasmid-mediated quinolone resistance genes and extended-spectrum beta-lactamases in non-typhoidalVeterinary world · 2022Article
- Distribution of fluoroquinolone resistance determinants in Carbapenem-resistant Klebsiella pneumoniae clinical isolates associated with bloodstream infections in China.BMC microbiology · 2021Article
- Article
- Prevalence and Characterization of Plasmid-Mediated Quinolone Resistance DeterminantsJournal of microbiology and biotechnology · 2020Article
- Profile of Enterobacteria Resistant to Beta-Lactams.Antibiotics (Basel, Switzerland) · 2020Article
- Lineage, Antimicrobial Resistance and Virulence of Citrobacter spp.Pathogens (Basel, Switzerland) · 2020Article
- Detection of 5 Kinds of Genes Related to Plasmid-Mediated Quinolone Resistance in Four Species of Nonfermenting Bacteria with 2 Drug Resistant Phenotypes.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2020Article
- Characterization of the complete sequences and stability of plasmids carrying the genes aac(6')-Ib-cr or qnrS in Shigella flexneri in the Hangzhou area of China.World journal of microbiology & biotechnology · 2018Article
- Detection of plasmid-mediated quinolone resistance in clinical isolates ofSaudi journal of biological sciences · 2018Article
- Genetic Diversity, Multidrug Resistance, and Virulence ofFrontiers in cellular and infection microbiology · 2018Article
- Revisiting Polymorphic Diversity of AminoglycosideFrontiers in microbiology · 2018Article
- Bacterial plasmid-mediated quinolone resistance genes in aquatic environments in China.Scientific reports · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quinolone resistance is an emerging problem in China. To investigate the prevalence of the plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr, a total of 265 clinical isolates of Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, and Enterobacter cloacae with ciprofloxacin MICs of > or =0.25 microg/ml were screened at nine teaching hospitals in China. The qnrA, qnrB, qnrS, and aac(6')-Ib genes were detected by PCR. The aac(6')-Ib-cr gene was further identified by digestion with BtsCI and/or direct sequencing. The qnr gene was present in significantly smaller numbers of isolates with cefotaxime MICs of <2 microg/ml than isolates with higher MICs (> or =2.0 microg/ml) (20.6% and 42.1%, respectively; P < 0.05). aac(6')-Ib-cr was present in 17.0% of the isolates tested, and 7.9% of the isolates carried both the qnr and the aac(6')-Ib-cr genes. Among the isolates with cefotaxime MICs of > or =2.0 microg/ml, qnr and aac(6')-Ib-cr were present in 65.7% and 8.6% of E. cloacae isolates, respectively; 65.5% and 21.8% of K. pneumoniae isolates, respectively; 63.3% and 26.7% of C. freundii isolates, respectively; and 6.5% and 16.9% of E. coli isolates, respectively. The 20 transconjugants showed 16- to 128-fold increases in ciprofloxacin MICs, 14 showed 16- to 2,000-fold increases in cefotaxime MICs, and 5 showed 8- to 32-fold increases in cefoxitin MICs relative to those of the recipient due to the cotransmission of bla(CTX-M-14), bla(CTX-M-3), bla(DHA-1), bla(SHV-2), and bla(SHV-12) with the qnr and aac(6')-Ib-cr genes. Southern hybridization analysis showed that these genes were located on large plasmids of different sizes (53 to 193 kb). These findings indicate the high prevalence of qnr and aac(6')-Ib-cr in members of the family Enterobacteriaceae and the widespread dissemination of multidrug resistance in China.
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