ArticleProceedings of the National Academy of Sciences of the United States of America2008
Ancient origin of the gene encoding involucrin, a precursor of the cross-linked envelope of epidermis and related epithelia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Comparative Transcriptomics Reveals a Dual Role of the Epidermal Differentiation Complex in the Skin and the Oesophagus.Experimental dermatology · 2025Article
- Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures.Animals : an open access journal from MDPI · 2025Review
- Integrated metagenomics and transcriptomics analysis reveals pathways associated with oral periapical lesions formation and progression.Current research in microbial sciences · 2025Article
- Article
- Comparative genomics of monotremes provides insights into the early evolution of mammalian epidermal differentiation genes.Scientific reports · 2024Article
- Development-Associated Genes of the Epidermal Differentiation Complex (EDC).Journal of developmental biology · 2024Review
- The Story of the Finest Armor: Developmental Aspects of Reptile Skin.Journal of developmental biology · 2023Review
- Thermostable Proteins from HaCaT Keratinocytes Identify a Wide Breadth of Intrinsically Disordered Proteins and Candidates for Liquid-Liquid Phase Separation.International journal of molecular sciences · 2022Article
- Keratin Promotes Differentiation of Keratinocytes Seeded on Collagen/Keratin Hydrogels.Bioengineering (Basel, Switzerland) · 2022Article
- Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model.International journal of molecular sciences · 2022Article
- Evolutionary diversification of epidermal barrier genes in amphibians.Scientific reports · 2022Article
- Article
- 3D skin models in domestic animals.Veterinary research · 2021Review
- Complex Gene Loss and Duplication Events Have Facilitated the Evolution of Multiple Loricrin Genes in Diverse Bird Species.Genome biology and evolution · 2019Article
- Comparative Analysis of Epidermal Differentiation Genes of Crocodilians Suggests New Models for the Evolutionary Origin of Avian Feather Proteins.Genome biology and evolution · 2018Article
- Review: cornification, morphogenesis and evolution of feathers.Protoplasma · 2017Review
- Review: mapping epidermal beta-protein distribution in the lizard Anolis carolinensis shows a specific localization for the formation of scales, pads, and claws.Protoplasma · 2016Review
- Comparative Genomics Identifies Epidermal Proteins Associated with the Evolution of the Turtle Shell.Molecular biology and evolution · 2016Article
- Recent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus.Frontiers in genetics · 2016Article
- Evolutionary origin and diversification of epidermal barrier proteins in amniotes.Molecular biology and evolution · 2014Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cross-linked (cornified) envelope is a characteristic product of terminal differentiation in the keratinocyte of the epidermis and related epithelia. This envelope contains many proteins of which involucrin was the first to be discovered and shown to become cross-linked by a cellular transglutaminase. Involucrin has evolved greatly in placental mammals, but retains the glutamine repeats that make it a good substrate for the transglutaminase. Until recently, it has been impossible to detect involucrin outside the placental mammals, but analysis of the GenBank and Ensembl databases that have become available since 2006 reveals the existence of involucrin in marsupials and birds. We describe here the properties of these involucrins and the ancient history of their evolution.
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