ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2008
Delirium after elective surgery among elderly patients taking statins.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01623297 (Cognitive Changes After Surgery in the Elderly), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cognitive Changes After Surgery in the Elderly: Does Minimally Invasive Surgery Influence the Incidence of Postoperative Cognitive Changes Compared to Open Colon Surgery?
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Preoperative medication use and postoperative delirium: a systematic review.BMC geriatrics · 2017Pooled it
- Preoperative statins are associated with a reduced risk of postoperative delirium following vascular surgery.PloS one · 2018Trial
- Statins, LDL-C and Beyond: A Contemporary Review of Atherosclerotic Cardiovascular Risk Assessment and Management.Journal of lipid and atherosclerosis · 2026Review
- Statin use is associated with reduced delirium and improved short-term outcomes in critically ill patients with chronic kidney disease.European journal of medical research · 2025Article
- Impact of preoperative antidepressant use on surgical and functional outcomes of robot assisted radical prostatectomy.Scientific reports · 2025Article
- Association Between Statin Use in the Intensive Care Unit and Delirium in Patients Receiving Mechanical Ventilation: A Cross-Sectional Study.Health science reports · 2025Article
- Characterizing medical patients with delirium: A cohort study comparing ICD-10 codes and a validated chart review method.PloS one · 2024Article
- Article
- The Relationship between Delirium and Statin Use According to Disease Severity in Patients in the Intensive Care Unit.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Effects of Atorvastatin Therapy on Postoperative Delirium After Malignant Tumor Surgeries in Older Adults.Neuropsychiatric disease and treatment · 2022Article
- Preintervention imaging and intraoperative management care of the hypertrophic obstructive cardiomyopathy patient.Asian cardiovascular & thoracic annals · 2022Review
- Effects of perioperative rosuvastatin on postoperative delirium in elderly patients: A randomized, double-blind, and placebo-controlled trial.World journal of clinical cases · 2021Article
- Effect of atorvastatin on delirium status of patients in the intensive care unit: a randomized controlled trial.Archives of medical science : AMS · 2021Article
- Association of Duration of Surgery With Postoperative Delirium Among Patients Receiving Hip Fracture Repair.JAMA network open · 2019Article
- Cardiovascular Outcomes of PCSK9 Inhibitors: With Special Emphasis on Its Effect beyond LDL-Cholesterol Lowering.Journal of lipids · 2018Review
- Evaluation of algorithms to identify delirium in administrative claims and drug utilization database.Pharmacoepidemiology and drug safety · 2017Article
- Effect of delirium motoric subtypes on administrative documentation of delirium in the surgical intensive care unit.Journal of clinical monitoring and computing · 2017Article
- Statins for delirium in ICU patients: a negative trial but a positive step.Journal of thoracic disease · 2016Article
- Prevention of Post-operative Delirium in the Elderly Using Pharmacological Agents.Canadian geriatrics journal : CGJ · 2016Review
- Association of rosuvastatin and delirium in severe sepsis with acute respiratory distress syndrome.Journal of thoracic disease · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative delirium after elective surgery is frequent and potentially serious. We sought to determine whether the use of statin medications was associated with a higher risk of postoperative delirium than other medications that do not alter microvascular autoregulation.
methodsWe conducted a retrospective cohort analysis of 284 158 consecutive patients in Ontario aged 65 years and older who were admitted for elective surgery. We identified exposure to statins from outpatient pharmacy records before admission. We identified delirium by examining hospital records after surgery.
resultsAbout 7% (n = 19 501) of the patients were taking statins. Overall, 3195 patients experienced postoperative delirium; the rate was significantly higher among patients taking statins (14 per 1000) than among those not taking statins (11 per 1000) (odds ratio [OR] 1.30, 95% confidence interval [CI] 1.15-1.47, p < 0.001). The increased risk of postoperative delirium persisted after we adjusted for multiple demographic, medical and surgical factors (OR 1.28, 95% CI 1.12-1.46) and exceeded the increased risk of delirium associated with prolonging surgery by 30 minutes (OR 1.20, 95% CI 1.19-1.21). The relative risk associated with statin use was somewhat higher among patients who had noncardiac surgery than among those who had cardiac surgery (adjusted OR 1.33, 95% CI 1.16-1.53), and extended to more complicated cases of delirium. We did not observe an increased risk of delirium with 20 other cardiac or noncardiac medications.
interpretationThe use of statins is associated with an increased risk of postoperative delirium among elderly patients undergoing elective surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.