ArticleThe Journal of cell biology2008
Gene associations: true romance or chance meeting in a nuclear neighborhood?
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- A misplaced lncRNA causes brachydactyly in humans.The Journal of clinical investigation · 2012Trial
- Nuclear speckles: a fundamental layer of gene regulation.Trends in cell biology · 2026Review
- The periphery of nuclear speckles defines a spatially and temporally regulated compartment of long-lived intron-retained RNAs that resolves during mitosis.Nature cell biology · 2026Article
- Article
- SPRITE: a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding.Nature protocols · 2022Review
- Inter-chromosomal Contact Properties in Live-Cell Imaging and in Hi-C.Molecular cell · 2018Article
- Heterochromatin instability in cancer: from the Barr body to satellites and the nuclear periphery.Seminars in cancer biology · 2013Review
- A multifaceted FISH approach to study endogenous RNAs and DNAs in native nuclear and cell structures.Current protocols in human genetics · 2013Article
- Ultrastructural study of transcription factories in mouse erythroblasts.Journal of cell science · 2011Article
- N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.Nature chemical biology · 2011Article
- Spatial Organization and Dynamics of Transcription Elongation and Pre-mRNA Processing in Live Cells.Genetics research international · 2011Article
- Article
- A role for TREX components in the release of spliced mRNA from nuclear speckle domains.Nature communications · 2010Article
- Gene positioning.Cold Spring Harbor perspectives in biology · 2010Review
- Interchromosomal association and gene regulation in trans.Trends in genetics : TIG · 2010Review
- Centromeric localization of dispersed Pol III genes in fission yeast.Molecular biology of the cell · 2010Article
- The nuclear periphery of embryonic stem cells is a transcriptionally permissive and repressive compartment.Journal of cell science · 2009Article
- Chromatin dynamics is correlated with replication timing.Chromosoma · 2009Article
- Subnuclear compartmentalization of transiently expressed polyadenylated pri-microRNAs: processing at transcription sites or accumulation in SC35 foci.Cell cycle (Georgetown, Tex.) · 2009Article
- The meaning of gene positioning.Cell · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many recent studies have raised interest in the nuclear associations of coregulated genes from different chromosomes, often evoking interpretations of gene-gene interactions, communication, and even "romance." However, in some cases, the associations may be indirect and infrequent and may reflect the segregation of active and inactive genes into different nuclear compartments. The study by Brown et al. (see p. 1083 of this issue) reports that the apparent association of erythroid genes is not a direct interaction nor colocalization to one tiny transcription factory but arises as a result of the known clustering of many active genes with larger splicing factor-rich speckles (a.k.a., SC35-defined domains). This clustering appears largely stochastic but is impacted by the chromosomal neighborhood of the gene as well as its transcriptional status. The study adds a new twist by examining the same gene in a foreign chromosomal context, providing evidence that this impacts a gene's propensity to form gene-domain (or apparent gene-gene) associations within nuclei.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.