ArticleMolecular and cellular biology2008
Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Septin crosstalk with microtubules and actin is regulated by a GSK3-dependent phosphoswitch.bioRxiv : the preprint server for biology · 2026Article
- Septin5 deficiency impairs both recent and remote contextual fear memory.Molecular brain · 2025Article
- Comprehensive behavioral phenotyping of male Septin 3-deficient mice reveals task-specific abnormalities.Molecular brain · 2025Article
- Septin complexes: Ahead of the curve.Cytoskeleton (Hoboken, N.J.) · 2025Article
- SEPT3 as a Potential Molecular Target of Triple-Negative Breast Cancer.International journal of general medicine · 2024Article
- Neural Marker Expression in Adipose-Derived Stem Cells Grown in PEG-Based 3D Matrix Is Enhanced in the Presence of B27 and CultureOne Supplements.International journal of molecular sciences · 2023Article
- Neuronal-specific septin-3 binds Atg8/LC3B, accumulates and localizes to autophagosomes during induced autophagy.Cellular and molecular life sciences : CMLS · 2022Article
- Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer's disease animal model.Cellular and molecular life sciences : CMLS · 2020Article
- Production and analysis of a mammalian septin hetero-octamer complex.Cytoskeleton (Hoboken, N.J.) · 2020Article
- Systematic Humanization of the Yeast Cytoskeleton Discerns Functionally Replaceable from Divergent Human Genes.Genetics · 2020Article
- In the line-up: deleted genes associated with DiGeorge/22q11.2 deletion syndrome: are they all suspects?Journal of neurodevelopmental disorders · 2019Review
- Functional Redundancy of Septin Homologs in Dendritic Branching.Frontiers in cell and developmental biology · 2017Article
- Expression ofFrontiers in neuroanatomy · 2017Article
- Partial Functional Diversification of Drosophila melanogaster Septin Genes Sep2 and Sep5.G3 (Bethesda, Md.) · 2016Article
- A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.Nature communications · 2015Article
- Structural and Thermodynamic Properties of Septin 3 Investigated by Small-Angle X-Ray Scattering.Biophysical journal · 2015Article
- Septin dynamics are essential for exocytosis.The Journal of biological chemistry · 2015Article
- Cell type-specific expression of SEPT3-homology subgroup members controls the subunit number of heteromeric septin complexes.Molecular biology of the cell · 2014Article
- Septin functions in organ system physiology and pathology.Biological chemistry · 2014Review
- Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The septin family of GTPases, first identified for their roles in cell division, are also expressed in postmitotic tissues. SEPT3 (G-septin) and SEPT5 (CDCrel-1) are highly expressed in neurons, enriched in presynaptic terminals, and associated with synaptic vesicles. These characteristics suggest that SEPT3 or SEPT5 might be important for synapse formation, maturation, or synaptic vesicle traffic. Since Sept5(-/-) mice do not show any overt neurological phenotypes, we generated Sept3(-/-) and Sept3(-/-) Sept5(-/-) mice and found that SEPT3 and SEPT5 are not essential for development, fertility, or viability. Changes in the expression of septins were noted in the absence of SEPT3, SEPT5, and both septins. SEPT5 association with other septins in brain tissue was unaffected by the removal of SEPT3. No abnormalities were observed in the gross morphology and synapses of the hippocampus. Similarly, axon development and synapse formation were unaffected in vitro. In cultured hippocampal neurons, the size of the recycling synaptic vesicle pool was unaltered in the absence of SEPT3. Furthermore, synaptic transmission at two different central synapses was not significantly affected in Sept3(-/-) Sept5(-/-) mice. These results indicate that SEPT3 and SEPT5 are dispensable for neuronal development as well as for synaptic vesicle fusion and recycling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.