ArticleAutonomic neuroscience : basic & clinical2008
Pressor responses to nasal stimulation are unaltered after disrupting the CPA.
Article in Autonomic neuroscience : basic & clinical, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Medullary dorsal horn neurons activated during voluntary diving express neurotransmitter receptors for glutamate and substance P.IBRO neuroscience reports · 2026Article
- Repetitive Diving in Trained Rats Still Increases Fos Production in Brainstem Neurons after Bilateral Sectioning of the Anterior Ethmoidal Nerve.Frontiers in physiology · 2016Article
- The mammalian diving response: an enigmatic reflex to preserve life?Physiology (Bethesda, Md.) · 2013Review
- Persistence of the nasotrigeminal reflex after pontomedullary transection.Respiratory physiology & neurobiology · 2012Article
- Activation of brainstem neurons by underwater diving in the rat.Frontiers in physiology · 2012Article
- Cardiorespiratory and neural consequences of rats brought past their aerobic dive limit.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- The rat: a laboratory model for studies of the diving response.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Stimulation of either the caudal pressor area (CPA) in the most caudal ventrolateral medulla with glutamate, or the nasal mucosa with ammonia vapors, induces an increase in mean arterial blood pressure (MABP). In the present study, we determined if neurons in the CPA serve as a relay for the increase in MABP seen after nasal stimulation. Ammonia vapors stimulated the nasal mucosa of rats anesthetized with either urethane alone or ketamine/xylazine and urethane to induce an increase in MABP, a bradycardia, and an apnea. Bilateral injections (50 nl) of glycine (1 M) or muscimol (2 mM) were placed in the CPA and the nasal mucosa again stimulated. The increases in MABP, the bradycardia and the duration of apnea to nasal stimulation were unchanged after either injection. However, resting MABP and HR were decreased significantly after glycine injections and resting MABP and resting respiratory rate were decreased after muscimol injections. The increase in MABP seen with nasal stimulation also did not change after multiple bilateral injections (3x40 nl) of ibotenate (5 microg/microl) in the CPA, but the bradycardia was eliminated and the duration of apnea was significantly shorter. These results suggest that the increase in MABP induced by nasal stimulation is via routes that do not include neurons in the CPA.
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