Evidence map›Paper›PMID 18809146›Full record

ReviewThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2008

Human papillomavirus-related diseases: oropharynx cancers and potential implications for adolescent HPV vaccination.

Maura L Gillison

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00897273 completednot on this map

Human Papillomavirus Infection of the Mouth in Young Men and Risk Factors for Oropharyngeal Cancer

TypeobservationalSponsorSidney Kimmel Comprehensive Cancer Center at Johns HopkinsRan2007 to 2009Enrolled500ConditionsHead and Neck Cancer, Infection, Precancerous ConditionArmscomparative genomic hybridization, gene expression analysis, study of socioeconomic and demographic variables, evaluation of cancer risk factors, study of high risk factors
NCT05023863 phase2 / phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients

TypeinterventionalSponsorAin Shams UniversityRan2021 to 2022Enrolled70ConditionsRadiation-Induced MucositisArmsAlpha Lipoic Acid 600 MG Oral Tablets, Placebo tablets, radiation or concurrent chemoradiation
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 154 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. HPV Infection and Oral Microbiota: Interactions and Future Implications.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Oral HPV prevalence and HPV vaccination among special needs population in the US.Papillomavirus research (Amsterdam, Netherlands) · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Maura L GillisonThe Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA. gillima@jhmi.edu
Johns Hopkins University · US

Funding

Oral HPV Infection in HIV-Infected Men and WomenR01DE016631 · NIDCR · OHIO STATE UNIVERSITY · PI GILLISON, MAURA L · 2005 to 2008
$2.5M
NIDCR NIH HHS DE016631-02NIDCR NIH HHS R01 DE016631
6 · The paper itself

Abstract

Molecular and epidemiological data now support an etiologic role for oncogenic human papillomavirus (HPV) in oral cancers in women and men. Recent studies have demonstrated an increase in the incidence of HPV-associated oral cancers in the United States. Moreover, the incidence rates for these cancers are higher in men than women. Oral HPV infections acquired through oral sex appear to be the principal risk factor for HPV-associated oral cancers. Despite reports in the popular press that the prevalence of oral sexual behaviors is increasing in the adolescent population, trends in these behaviors over time are largely unavailable. However, data indicate that oral-genital contact is frequently practiced among adolescents; adolescents do not typically consider this a risky behavior. The majority of oral cancers (approximately 90%) caused by HPV are identified as HPV 16 positive. Therefore, HPV-associated oral cancers could be prevented by a prophylactic vaccine if the vaccine were demonstrated to be capable of preventing oral HPV 16 infection. These findings have created new potential opportunities for the primary prevention of oral cancers.

Indexed as

AdolescentAdolescent BehaviorAdultFemaleHuman papillomavirus 16HumansIncidenceMaleOropharyngeal NeoplasmsPapillomavirus InfectionsPapillomavirus VaccinesSex FactorsSexual BehaviorUnited StatesPapillomavirus Vaccines

Identifiers

PMID18809146
PMCPMC3037092
OpenAlexW2044757593

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.