SynthesisDrugs & aging2008
Use of antidepressants in late-life depression.
Synthesis in Drugs & aging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Depression in adults: drug and physical treatments.BMJ clinical evidence · 2011Pooled it
- Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women's Health Initiative Memory Study.International psychogeriatrics · 2012Trial
- Late-life depression: issues for the general practitioner.International journal of general medicine · 2018Review
- Directions for Effectiveness Research to Improve Health Services for Late-Life Depression in the United States.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Review
- A systematic approach to pharmacotherapy for geriatric major depression.Clinics in geriatric medicine · 2014Review
- [Pharmacotherapy of depression in the elderly].Zeitschrift fur Gerontologie und Geriatrie · 2013Article
- Contemporary concepts in the pharmacotherapy of depression in older people.Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC · 2012Article
- Dopaminergic and serotonergic drug use: a nationwide register-based study of over 1,300,000 older people.PloS one · 2011Article
- Pharmacotherapy for late-life depression.The Journal of clinical psychiatry · 2011Article
- Late-life depression with comorbid cognitive impairment and disability: nonpharmacological interventions.Clinical interventions in aging · 2010Review
- Psychotropic drug use among older people in general practice: discrepancies between opinion and practice.The British journal of general practice : the journal of the Royal College of General Practitioners · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Late-life depression (LLD) is a common and typically recurrent illness that is often unrecognized and under-treated. It is associated with significant co-morbidities and poor health outcomes. Antidepressants are typically used as a first-line treatment for LLD. We performed a systematic review of the English literature (1996 to August 2007) and present results relevant to the efficacy of antidepressants in acute and maintenance pharmacotherapy of LLD, the predictors of LLD treatment outcomes and pharmacological strategies for non-remission. There is a consensus in the literature that the goal of treatment should be remission. Although antidepressants can be categorized into several classes based on their putative mechanisms of action, there is no consistent evidence that antidepressants from different classes are associated with different rates of remission of LLD. After achieving remission, the evidence supports a beneficial role of maintenance pharmacotherapy in reducing the rate of recurrence of LLD for at least 2 years. There are reports of a number of possible augmentation and switching strategies that can be used when LLD remission is not attained. However, none of these various strategies has been studied rigorously in patients with LLD as yet. Overall, the current literature is adequate for guiding acute and maintenance pharmacotherapy of LLD but further research is urgently needed to guide clinical strategies in non-remission.
Indexed as
Identifiers
18808208What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.