ReviewHeart failure reviews2009
Obstructive sleep apnea: the new cardiovascular disease. Part I: Obstructive sleep apnea and the pathogenesis of vascular disease.
Review in Heart failure reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04021550 (Combined Treatment of Angiotensin Receptor Blocker and Antioxidant Supplementation as a Novel Adjunctive Therapy for 24-hour Blood Pressure Improvement in Obstructive Sleep Apnea), which is not on this map. Cited by 37 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combined Treatment of Angiotensin Receptor Blocker and Antioxidant Supplementation as a Novel Adjunctive Therapy for 24-hour Blood Pressure Improvement in Obstructive Sleep Apnea
Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Diagnostic accuracy of artificial intelligence for obstructive sleep apnea detection: a systematic review.BMC medical informatics and decision making · 2025Pooled it
- Meta-analysis of changes in the levels of catecholamines and blood pressure with continuous positive airway pressure therapy in obstructive sleep apnea.Journal of clinical hypertension (Greenwich, Conn.) · 2021Pooled it
- Obstructive sleep apnea and cerebral white matter change: a systematic review and meta-analysis.Journal of neurology · 2018Pooled it
- Pooled it
- Improving Obstructive Sleep Apnoea Mitigates Dampened Heart Rate Responses to Respiratory Events in Children With Down Syndrome.Journal of sleep research · 2025Article
- Does Surgical Treatment With Uvulopalatopharyngoplasty for Obstructive Sleep Apnea Prevent Future Arrhythmic Events?Pacing and clinical electrophysiology : PACE · 2025Article
- Vascular density changes in retina and optic nerve in obstructive sleep apnea syndrome cases.Sleep & breathing = Schlaf & Atmung · 2025Article
- Advancements in the neurocirculatory reflex response to hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Review
- Atherosclerosis: From Molecular Biology to Therapeutic Perspective 3.0.International journal of molecular sciences · 2023Article
- Hypothalamic Oxytocin Neuron Activation Attenuates Intermittent Hypoxia-Induced Hypertension and Cardiac Dysfunction in an Animal Model of Sleep Apnea.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Association between obstructive sleep apnea and cardiovascular diseases.Acta biochimica et biophysica Sinica · 2022Review
- Retinal Vascular Changes in Patients with Chronic Obstructive Pulmonary Disease: An Optical Coherence Tomography Angiography Study.Sisli Etfal Hastanesi tip bulteni · 2021Article
- PDE1 or PDE5 inhibition augments NO-dependent hypoxic constriction of porcine coronary artery via elevating inosine 3',5'-cyclic monophosphate level.Journal of cellular and molecular medicine · 2020Article
- Risk of major cardiovascular and neurologic events with obstructive sleep apnea among patients with atrial fibrillation.American heart journal · 2020Article
- Metallothionein induction attenuates the progression of lung injury in mice exposed to long-term intermittent hypoxia.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Cardiac rhythm disorders in obstructive sleep apnea.Journal of thoracic disease · 2018Review
- Association of sleep problems with neuroendocrine hormones and coagulation factors in patients with acute myocardial infarction.BMC cardiovascular disorders · 2018Article
- Chronic intermittent hypoxia exposure induces kidney injury in growing rats.Sleep & breathing = Schlaf & Atmung · 2018Article
- Among middle-aged adults, snoring predicted hypertension independently of sleep apnoea.The Journal of international medical research · 2018Article
- Inflammatory and oxidative stress‑associated factors in chronic intermittent hypoxia in Chinese patients, rats, lymphocytes and endotheliocytes.Molecular medicine reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Obstructive sleep apnea (OSA) is increasingly recognized as a novel cardiovascular risk factor. OSA is implicated in the pathogenesis of hypertension, left ventricular dysfunction, coronary artery disease and stroke. OSA exerts its negative cardiovascular consequences through its unique pattern of intermittent hypoxia. Endothelial dysfunction, oxidative stress, and inflammation are all consequences of OSA directly linked to intermittent hypoxia and critical pathways in the pathogenesis of cardiovascular disease in patients with OSA. This review will discuss the known mechanisms of vascular dysfunction in patients with OSA and their implications for cardiovascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.