ArticleMedical molecular morphology2008
Signet-ring stromal tumor of the ovary: an immunohistochemical and ultrastructural study with a review of the literature.
Article in Medical molecular morphology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 25 citations in OpenAlex.
- A Rare Case of Primary Ovarian Mucinous Carcinoma with Signet-Ring Cells and Literature Review.Turk patoloji dergisi · 2026Review
- Review
- Signet-ring stromal tumor of the ovary: an extremely rare neoplasm.Journal of the Turkish German Gynecological Association · 2011Article
- Primary signet ring cell mucinous ovarian carcinoma: a case report and literature review.Case reports in oncology · 2010Article
- Oncogenic Activation of the Wnt/β-Catenin Signaling Pathway in Signet Ring Stromal Cell Tumor of the Ovary.Applied immunohistochemistry & molecular morphology : AIMMArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signet-ring stromal tumor is a very rare type of ovarian neoplasm. Only ten cases of this tumor have been reported in the English literature. We report here an additional case of this type of tumor that arose from the left ovary in a 76-year-old woman. By light microscopy, the tumor was composed of small round and oval cells with cytoplasmic vacuolization and a typical signet-ring appearance, focally admixed with fibromatous tissue. Special staining revealed that the vacuoles of the tumor cells contained no lipid, mucoprotein, or glycogen. Interestingly, variously sized hyaline globule-like structures positive for periodic acid-Schiff (PAS) reaction with and without diastase digestion were present in the cytoplasm of tumor cells. Immunohistochemically, the tumor cells variously expressed several markers, including CD56, inhibin-alpha, alpha-smooth muscle actin (alpha-SMA), and progesterone receptor (PR), which have been identified in ovarian sex cord-stromal neoplasms. Ultrastructurally, the hyaline globule-like structures in tumor cells appeared to be lysosomes, and the vacuoles in the cells appeared to have resulted from pseudoinclusions of extracellular edematous matrix.
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Registered trials
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