ArticleClinical rheumatology2009
Analyses of differential proteome of human synovial fibroblasts obtained from arthritis.
Article in Clinical rheumatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.Cell death & disease · 2021Article
- Article
- S100B regulates inflammatory response during osteoarthritis via fibroblast growth factor receptor 1 signaling.Molecular medicine reports · 2018Article
- The Tumor-Like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine.Arthritis & rheumatology (Hoboken, N.J.) · 2018Review
- Genomics, transcriptomics and proteomics to elucidate the pathogenesis of rheumatoid arthritis.Rheumatology international · 2017Review
- The metastasis-associated protein S100A4 may be a new potential therapeutic target for rheumatoid arthritis.Clinical rheumatology · 2016Article
- Proteomics in Rheumatoid Arthritis Research.Immune network · 2015Review
- Comprehensive protein profiling of synovial fluid in osteoarthritis following protein equalization.Osteoarthritis and cartilage · 2015Article
- Subchondral bone proteomics in osteoarthritis: Current status and perspectives.Journal of orthopaedic translation · 2015Review
- Identification of autoantibodies against transthyretin for the screening and diagnosis of rheumatoid arthritis.PloS one · 2014Article
- Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues.Arthritis and rheumatism · 2013Article
- Epidermal growth factor receptor (EGFR) as a therapeutic target in rheumatoid arthritis.Clinical rheumatology · 2013Review
- Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes.The international journal of biochemistry & cell biology · 2012Article
- Analysis of synovial fluid in knee joint of osteoarthritis:5 proteome patterns of joint inflammation based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.International orthopaedics · 2012Article
- High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation.Journal of proteomics · 2011Article
- Proteomics in rheumatology: the dawn of a new era.F1000 medicine reports · 2010Article
- BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.Arthritis research & therapy · 2009Article
- A systems biology approach to synovial joint lubrication in health, injury, and disease.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is mounting evidence indicating that the synovial fibroblasts (SFs) contribute to the pathogenesis of rheumatoid arthritis (RA). The present study showed the differential proteins expression pattern of SFs from patients with RA or osteoarthritis (OA) and healthy control. Cellular proteins of cultured SFs were subjected to 2-DE and visualized by silver nitrate staining. A total of 49 spots that were statistically and differentially overexpressed in RA or OA in comparison to healthy ones were identified by MALDI-TOF-MS, and 25 proteins were successfully identified. Western blot was used to further verify some of the differential proteins. These proteins included enzymatic and structural proteins, signal transduction proteins, calcium binding protein, etc. From all of the identified proteins, a number of proteins have been implicated that involved in the healthy or pathological SFs function (e.g., S100A4, S100A10, cathepsin D) or that have potential diagnostic and prognostic value for RA (alpha-enolase and TPI) or that may be the new therapeutic targets (Annexin, SOD, PRX).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.