Trial reportIntensive care medicine2009
The influence of a balanced volume replacement concept on inflammation, endothelial activation, and kidney integrity in elderly cardiac surgery patients.
Trial report in Intensive care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Perioperative administration of buffered versus non-buffered crystalloid intravenous fluid to improve outcomes following adult surgical procedures.The Cochrane database of systematic reviews · 2017Pooled it
- Prevention of acute kidney injury and protection of renal function in the intensive care unit. Expert opinion of the Working Group for Nephrology, ESICM.Intensive care medicine · 2010Guideline
- Restricted intravenous fluid regimen reduces the rate of postoperative complications and alters immunological activity of elderly patients operated for abdominal cancer: a randomized prospective clinical trail.World journal of surgery · 2012Trial
- Retraction Note to: The impact of fluid therapy on microcirculation and tissue oxygenation in hypovolemic patients: a review.Intensive care medicine · 2020Article
- Ethical publishing in intensive care medicine: A narrative review.World journal of critical care medicine · 2016Review
- Frequency of discrepancies in retracted clinical trial reports versus unretracted reports: blinded case-control study.BMJ (Clinical research ed.) · 2015Article
- The role of transesophageal echocardiography in the intraoperative period.Current cardiology reviews · 2011Review
- Are renal adverse effects of hydroxyethyl starches merely a consequence of their incorrect use?Wiener klinische Wochenschrift · 2011Review
- Colloid solutions: a clinical update.Journal of anesthesia · 2010Review
- Update on transfusion solutions during surgery: review of hydroxyethyl starches 130/0.4.International journal of general medicine · 2010Article
- Acute kidney injury in elderly intensive care patients: a review.Intensive care medicine · 2010Review
- The impact of fluid therapy on microcirculation and tissue oxygenation in hypovolemic patients: a review.Intensive care medicine · 2010Review
- S3 guidelines for intensive care in cardiac surgery patients: hemodynamic monitoring and cardiocirculary system.German medical science : GMS e-journal · 2010Article
- The impact of crystalloid and colloid infusion on the kidney in rodent sepsis.Intensive care medicine · 2010Article
- Year in review in Intensive Care Medicine 2009: II. Neurology, cardiovascular, experimental, pharmacology and sedation, communication and teaching.Intensive care medicine · 2010Article
- Year in review 2009: Critical Care--shock.Critical care (London, England) · 2010Review
- A balanced view of balanced solutions.Critical care (London, England) · 2010Review
- Bench-to-bedside review: Chloride in critical illness.Critical care (London, England) · 2010Review
Corrections and comments
- Retraction · 2011-05-21Concerns/Issues about Data · Ethical Violations by Author · Investigation by Company/Institution · Investigation by Third Party · Lack of IRB/IACUC Approval and/or Compliance ·
- Retracted
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA balanced fluid replacement strategy appears to be promising for correcting hypovolemia. The benefits of a balanced fluid replacement regimen were studied in elderly cardiac surgery patients.
methodsIn a randomized clinical trial, 50 patients aged >75 years undergoing cardiac surgery received a balanced 6% HES 130/0.42 plus a balanced crystalloid solution (n = 25) or a non-balanced HES in saline plus saline solution (n = 25) to keep pulmonary capillary wedge pressure/central venous pressure between 12-14 mmHg. Acid-base status, inflammation, endothelial activation (soluble intercellular adhesion molecule-1, kidney integrity (kidney-specific proteins glutathione transferase-alpha; neutrophil gelatinase-associated lipocalin) were studied after induction of anesthesia, 5 h after surgery, 1 and 2 days thereafter. Serum creatinine (sCr) was measured approximately 60 days after discharge.
resultsA total of 2,750 +/- 640 mL of balanced and 2,820 +/- 550 mL of unbalanced HES were given until the second POD. Base excess (BE) was significantly reduced in the unbalanced (from +1.21 +/- 0.3 to -4.39 +/- 1.0 mmol L(-1) 5 h after surgery; P < 0.001) and remained unchanged in the balanced group (from 1.04 +/- 0.3 to -0.81 +/- 0.3 mmol L(-1) 5 h after surgery). Evolution of the BE was significantly different. Inflammatory response and endothelial activation were significantly less pronounced in the balanced than the unbalanced group. Concentrations of kidney-specific proteins after surgery indicated less alterations of kidney integrity in the balanced than in the unbalanced group.
conclusionsA total balanced volume replacement strategy including a balanced HES and a balanced crystalloid solution resulted in moderate beneficial effects on acid-base status, inflammation, endothelial activation, and kidney integrity compared to a conventional unbalanced volume replacement regimen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.