Evidence map›Paper›PMID 18807006›Full record

ArticleIntensive care medicine2009

Diabetes mellitus is an independent risk factor for ICU-acquired bloodstream infections.

M Michalia, M Kompoti, A Koutsikou, A Paridou, P Giannopoulou, E Trikka-Graphakos, P Clouva-Molyvdas

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Intensive care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07261865 (Identifying Diabetes and Impaired Glucose Tolerance in ICU Patients and Assessing Their Impact on Organ Failure and Outcome.), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07261865 completednot on this mapstarted 2024, after this paper: background citation

Identifying Diabetes and Impaired Glucose Tolerance in ICU Patients and Assessing Their Impact on Organ Failure and Outcome.

Typeobservational_patient_registrySponsorUniversity Medical Center GroningenRan2024 to 2025Enrolled4,198ConditionsDiabetes (DM), Critical Illness
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
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  7. Article
  8. Epidemiology of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2023
    Article
  9. Article
  10. COVID-19 infection, progression, and vaccination: Focus on obesity and related metabolic disturbances.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Review
  11. Article
  12. Article
  13. Predicting Mortality in Diabetic ICU Patients Using Machine Learning and Severity Indices.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2018
    Article
  14. Article
  15. The Impact of Obesity and Diabetes on the Risk of Disease and Death due to Invasive Group A Streptococcus Infections in Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Article
  16. Is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016
    Article
  17. Poorly Regulated Blood Glucose in Diabetic Patients-predictor of Acute Infections.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2014
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

M MichaliaIntensive Care Unit, Thriassio General Hospital of Eleusis, Magoula, Attika, Greece.
M Kompoti
A Koutsikou
A Paridou
P Giannopoulou
E Trikka-Graphakos
P Clouva-Molyvdas
Thriasio General Hospital of Elefsina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the role of diabetes as risk factor for ICU-acquired bloodstream infections (BSI).

designProspective observational study.

settingA general eight-bed ICU of a tertiary hospital. PATIENTS: Three hundred and forty-three consecutive patients (63 diabetic and 280 nondiabetic) admitted in the ICU.

methodsBSI episodes in the ICU were recorded and classified as primary, secondary, catheter-related and mixed according to strict criteria. In all patients, blood glucose was strictly controlled with a continuous insulin infusion within a range of 80-120 mg/dl.

resultsOne-hundred and eighteen patients (34.4%) developed at least one BSI episode. Diabetic patients had an increased probability of developing at least one BSI episode compared with nondiabetic patients (hazard ratio = 1.66, 95% confidence interval 1.04-2.64, P = 0.034) in a Cox proportional hazards regression model adjusting for age, gender, admission category and APACHE II score at admission in the ICU and comorbidities.

conclusionsDespite strict glycemic control, diabetic patients have a 1.7-fold probability of developing an ICU-acquired BSI compared to nondiabetic subjects.

Indexed as

AgedBacterial InfectionsCross InfectionDiabetes MellitusFemaleHumansHypoglycemic AgentsInsulinIntensive Care UnitsMaleSepsisHypoglycemic AgentsInsulin

Identifiers

PMID18807006
OpenAlexW2065767176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.