ArticleEuropean archives of psychiatry and clinical neuroscience2009
Factors associated with choice of psychotropic drugs used for intentional drug overdose.
Article in European archives of psychiatry and clinical neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02869724 (Divided Drug Delivery), which is not on this map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Divided Drug Delivery : a Way to Prevent Repeated Volutary Drug Intoxications.
Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Trial
- Medicine Use Preceding Fatal Poisonings Among Individuals With Bipolar Disorder.Basic & clinical pharmacology & toxicology · 2026Article
- Development and validation of a prognostic nomogram for predicting of patients with acute sedative-hypnotic overdose admitted to the intensive care unit.Scientific reports · 2025Article
- Association between Prescribing and Intoxication Rates for Selected Psychotropic Drugs: A Longitudinal Observational Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Creating and evaluating the score to assess overdose: the OD score.BMC emergency medicine · 2024Article
- Clinical and demographic features with outcome predictors of adult patients with acute intoxication admitted to a medical intensive care unit in the Mediterranean part of Croatia.Toxicology research · 2023Article
- Evaluation of factors related to overdose in patients with impaired consciousness who are transported by emergency medical services: an age-specific research.Journal of pharmaceutical health care and sciences · 2021Article
- Repeat Self-Harm Following Hospital-Presenting Intentional Drug Overdose among Young People-A National Registry Study.International journal of environmental research and public health · 2020Article
- Relative toxicity of mood stabilisers and antipsychotics: case fatality and fatal toxicity associated with self-poisoning.BMC psychiatry · 2018Article
- Vortioxetine overdose in a suicidal attempt: A case report.Medicine · 2018Article
- Intentional Drug Overdose Involving Pregabalin and Gabapentin: Findings from the National Self-Harm Registry Ireland, 2007-2015.Clinical drug investigation · 2018Article
- Exposure to psychotropic medications prior to overdose: a case-control study.Psychopharmacology · 2015Article
- Characteristics of hospital-treated intentional drug overdose in Ireland and Northern Ireland.BMJ open · 2014Article
- Toxicity of antidepressants: rates of suicide relative to prescribing and non-fatal overdose.The British journal of psychiatry : the journal of mental science · 2010Article
- Association between suicide death and concordance with benzodiazepine treatment guidelines for anxiety and sleep disorders.General hospital psychiatryArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionKnowledge of the factors influencing the choice of drugs used for intentional drug overdose (IDO) may allow the reduction of IDO lethality.
objectivesTo assess with which frequency subjects with intentional overdose of psychotropic drugs ingest their own psychotropic drug treatment, and whether prescription of a drug may be a factor influencing the choice of drugs used for the IDO.
methodsDemographic characteristics, psychiatric history, and currently prescribed psychotropic drug treatment were collected for all the patients (n = 1,654) admitted to an emergency department (ED) for IDO with psychotropic drugs (anxiolytics, hypnotics, antidepressants, neuroleptics and mood stabilizers) over a period of 18 months. Drugs ingested for the IDO were compared in subjects who had ingested at least one psychotropic drug that was prescribed for them and subjects who had ingested psychotropic drugs not prescribed for them using multivariate logistic regression.
resultsTwo-thirds of the patients ingested during the IDO at least one of their own prescribed psychotropic drugs. Compared with the subjects who had ingested psychotropic drugs not prescribed for them, they were more likely to have a history of psychiatric hospitalization (OR 4.2; 95%CI 3.1-5.5), of being a psychiatric outpatient (OR 3.9; 95%CI 3.0-5.1), of parasuicide (OR 2.5; 95%CI 1.9-3.3) and a serious IDO (OR 2; 95%CI 1.4-2.9). Independently from age and psychiatric hospitalization history, they ingested during the IDO more often antidepressants (OR 4.4; 95%CI 3.0-6.4), antipsychotics (OR 2.9; 95%CI 1.7-4.8) and mood stabilizers (OR 4.1; 95%CI 1.6-10.7). No association was found with prescription for overdose of hypnotic (OR 1.1; 95%CI 0.8-1.5), anxiolytic (OR 1.2; 95%CI 0.9-1.7) or paracetamol (OR 1.0; 95%CI 0.5-2.1).
conclusionPrescription of the psychotropic drugs plays an important role in the choice of the drugs ingested for the IDO. It might make potentially "dangerous" drugs available for the patient. Physicians have always to balance the benefit of the treatment against the risk of drug overdose.
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