Evidence map›Paper›PMID 18806888›Full record

ArticleMicrofluidics and nanofluidics2008

Nanobiosensors: optofluidic, electrical and mechanical approaches to biomolecular detection at the nanoscale.

David Erickson, Sudeep Mandal, Allen H J Yang, Bernardo Cordovez

Abstract read
In one paragraph

Article in Microfluidics and nanofluidics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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  17. Lectin-carbohydrate interactions on nanoporous gold monoliths.New journal of chemistry = Nouveau journal de chimie · 2013
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David EricksonSibley School of Mechanical and Aerospace Engineering, Cornell University, 240 Upson Hall, Ithaca, NY 14853, USA.
Sudeep Mandal
Allen H J Yang
Bernardo Cordovez

Funding

Nanoscale Optofluidic Pathogen DetectionR21EB007031 · NIBIB · CORNELL UNIVERSITY · PI ERICKSON, DAVID CARL · 2007 to 2009
$554k
NIBIB NIH HHS R21 EB007031
6 · The paper itself

Abstract

Next generation biosensor platforms will require significant improvements in sensitivity, specificity and parallelity in order to meet the future needs of a variety of fields ranging from in vitro medical diagnostics, pharmaceutical discovery and pathogen detection. Nano-biosensors, which exploit some fundamental nanoscopic effect in order to detect a specific biomolecular interaction, have now been developed to a point where it is possible to determine in what cases their inherent advantages over traditional techniques (such as nucleic acid microarrays) more than offset the added complexity and cost involved constructing and assembling the devices. In this paper we will review the state of the art in nanoscale biosensor technologies, focusing primarily on optofluidic type devices but also covering those which exploit fundamental mechanical and electrical transduction mechanisms. A detailed overview of next generation requirements is presented yielding a series of metrics (namely limit of detection, multiplexibility, measurement limitations, and ease of fabrication/assembly) against which the various technologies are evaluated. Concluding remarks regarding the likely technological impact of some of the promising technologies are also provided.

Identifiers

PMID18806888
PMCPMC2544611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.