ArticleProceedings of the National Academy of Sciences of the United States of America2008
The convergence of carbohydrate active gene repertoires in human gut microbes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04841668 (Gut-Brain-axis), which is not on this map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly
Who cites it
70 citing papers in PubMed, 140 citations in OpenAlex.
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- Empirical Evidence That Complexity Limits Horizontal Gene Transfer.Genome biology and evolution · 2023Article
- Dissecting the HGT network of carbon metabolic genes in soil-borne microbiota.Frontiers in microbiology · 2023Article
- Bacteroides humanifaecis sp. nov., isolated from faeces of healthy Korean.Archives of microbiology · 2022Article
- Horizontal gene transfer and adaptive evolution in bacteria.Nature reviews. Microbiology · 2022Review
- Bifidobacterium castoris strains isolated from wild mice show evidence of frequent host switching and diverse carbohydrate metabolism potential.ISME communications · 2022Article
- Cell Surface Xyloglucan Recognition and Hydrolysis by the Human Gut Commensal Bacteroides uniformis.Applied and environmental microbiology · 2022Review
- Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome BacteriumMolecules (Basel, Switzerland) · 2021Article
- Mucin-Degrading Microbes Release Monosaccharides That ChemoattractACS infectious diseases · 2021Article
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- Effect of Diet on the Enteric Microbiome of the Wood-Eating CatfishFrontiers in microbiology · 2019Article
- Prokaryotic horizontal gene transfer within the human holobiont: ecological-evolutionary inferences, implications and possibilities.Microbiome · 2018Review
- Ecophylogenetics Clarifies the Evolutionary Association between Mammals and Their Gut Microbiota.mBio · 2018Article
- Phylogeny-corrected identification of microbial gene families relevant to human gut colonization.PLoS computational biology · 2018Article
- Interaction of antidiabetic α-glucosidase inhibitors and gut bacteria α-glucosidase.Protein science : a publication of the Protein Society · 2018Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
The extreme variation in gene content among phylogenetically related microorganisms suggests that gene acquisition, expansion, and loss are important evolutionary forces for adaptation to new environments. Accordingly, phylogenetically disparate organisms that share a habitat may converge in gene content as they adapt to confront shared challenges. This response should be especially pronounced for functional genes that are important for survival in a particular habitat. We illustrate this principle by showing that the repertoires of two different types of carbohydrate-active enzymes, glycoside hydrolases and glycosyltransferases, have converged in bacteria and archaea that live in the human gut and that this convergence is largely due to horizontal gene transfer rather than gene family expansion. We also identify gut microbes that may have more similar dietary niches in the human gut than would be expected based on phylogeny. The techniques used to obtain these results should be broadly applicable to understanding the functional genes and evolutionary processes important for adaptation in many environments and useful for interpreting the large number of reference microbial genome sequences being generated for the International Human Microbiome Project.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.