ArticleThe Plant cell2008
Genetic analysis reveals that C19-GA 2-oxidation is a major gibberellin inactivation pathway in Arabidopsis.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.
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Who cites it
155 citing papers in PubMed, 326 citations in OpenAlex.
- Light modulates organ-specific gibberellin-abscisic acid crosstalk during drought response in Arabidopsis thaliana.Planta · 2026Article
- Expression profiling of the gibberellin 2-oxidase gene CsGA2ox2 (Cucumis sativus L.) reveals stage- and tissue-specific transcript accumulation during fruit development.Molecular biology reports · 2026Article
- Functional insights into a putative 2-OG oxygenase involved in jasmonic acid metabolism and xylem development in Populus trichocarpa.Plant & cell physiology · 2026Article
- Germination-Related Universal Stress Protein (GRUSP) Is Involved in Abscisic Acid Responses During Imbibition and Early Post-Germination Growth ofInternational journal of molecular sciences · 2026Article
- SOT2/Growth-Regulating Factor 3 Modulates Salt Tolerance by Regulating Gibberellin-DELLA Signalling.Plant, cell & environment · 2026Article
- A two-step auxin-GA cross-talk regulates organ formation in tomato.Development (Cambridge, England) · 2026Article
- Functional Characterization ofPlants (Basel, Switzerland) · 2026Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- Identification of a novel link connecting indole-3-acetamide with abscisic acid biosynthesis and signaling.The New phytologist · 2026Article
- Artificial Selection on theInternational journal of molecular sciences · 2026Article
- The identification of gibberellin 2-oxidase gene family in cotton and functional analysis.BMC plant biology · 2026Article
- A Transcriptome Study on Seed Germination ofInternational journal of molecular sciences · 2026Article
- The genomic basis of local adaptation to photoperiod across altitude in a self-fertilizing monkeyflower.bioRxiv : the preprint server for biology · 2026Article
- The multifaceted role of gibberellins in somatic embryogenesis: fromFrontiers in plant science · 2026Review
- Integrating transcriptomic, physiological, and biochemical studies revealing the role of endogenous ABA and GAFrontiers in plant science · 2026Article
- Seed the Difference: QTL Mapping Reveals Several Major Loci for Seed Size inPlants (Basel, Switzerland) · 2025Article
- Plant hormones regulate inducible asexual reproduction in Kalanchoë pinnata.Journal of experimental botany · 2025Article
- Comparing hormone dynamics in cereal crops via transient expression of hormone sensors.Plant & cell physiology · 2025Article
- Gibberellin-induced parthenocarpy in fruits of a prickly pear mutant.Plant cell reports · 2025Article
- Gibberellin-deactivating GA2OX enzymes act as a hub for auxin-gibberellin cross talk inProceedings of the National Academy of Sciences of the United States of America · 2025Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Bioactive hormone concentrations are regulated both at the level of hormone synthesis and through controlled inactivation. Based on the ubiquitous presence of 2beta-hydroxylated gibberellins (GAs), a major inactivating pathway for the plant hormone GA seems to be via GA 2-oxidation. In this study, we used various approaches to determine the role of C(19)-GA 2-oxidation in regulating GA concentration and GA-responsive plant growth and development. We show that Arabidopsis thaliana has five C(19)-GA 2-oxidases, transcripts for one or more of which are present in all organs and at all stages of development examined. Expression of four of the five genes is subject to feed-forward regulation. By knocking out all five Arabidopsis C(19)-GA 2-oxidases, we show that C(19)-GA 2-oxidation limits bioactive GA content and regulates plant development at various stages during the plant life cycle: C(19)-GA 2-oxidases prevent seed germination in the absence of light and cold stimuli, delay the vegetative and floral phase transitions, limit the number of flowers produced per inflorescence, and suppress elongation of the pistil prior to fertilization. Under GA-limited conditions, further roles are revealed, such as limiting elongation of the main stem and side shoots. We conclude that C(19)-GA 2-oxidation is a major GA inactivation pathway regulating development in Arabidopsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.