ArticleBlood2008
Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code.
Article in Blood, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 43 citations in OpenAlex.
- Transcription factors regulating vasculogenesis and angiogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Review
- In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis.Nature communications · 2023Article
- Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.Epigenetics & chromatin · 2019Article
- Serial transplantation reveals a critical role for endoglin in hematopoietic stem cell quiescence.Blood · 2019Article
- Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models.Blood · 2017Article
- Article
- The analysis of novel distal Cebpa enhancers and silencers using a transcriptional model reveals the complex regulatory logic of hematopoietic lineage specification.Developmental biology · 2016Article
- GATA2 is required for lymphatic vessel valve development and maintenance.The Journal of clinical investigation · 2015Article
- Article
- Constrained transcription factor spacing is prevalent and important for transcriptional control of mouse blood cells.Nucleic acids research · 2014Article
- Transcriptional network control of normal and leukaemic haematopoiesis.Experimental cell research · 2014Review
- PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin.Oncogene · 2014Article
- Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.Developmental biology · 2014Article
- Article
- Transcriptional regulation of endothelial cell and vascular development.Circulation research · 2013Review
- Molecular pathways of early CD105-positive erythroid cells as compared with CD34-positive common precursor cells by flow cytometric cell-sorting and gene expression profiling.Blood cancer journal · 2013Article
- Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites.Genome research · 2012Article
- Endoglin expression level discriminates long-term hematopoietic from short-term clonogenic progenitor cells in the aorta.Haematologica · 2012Article
- Article
- Integration of Elf-4 into stem/progenitor and erythroid regulatory networks through locus-wide chromatin studies coupled with in vivo functional validation.Molecular and cellular biology · 2012Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
Endoglin is an accessory receptor for TGF-beta signaling and is required for normal hemangioblast, early hematopoietic, and vascular development. We have previously shown that an upstream enhancer, Eng -8, together with the promoter region, mediates robust endothelial expression yet is inactive in blood. To identify hematopoietic regulatory elements, we used array-based methods to determine chromatin accessibility across the entire locus. Subsequent transgenic analysis of candidate elements showed that an endothelial enhancer at Eng +9 when combined with an element at Eng +7 functions as a strong hemato-endothelial enhancer. Chromatin immunoprecipitation (ChIP)-chip analysis demonstrated specific binding of Ets factors to the promoter as well as to the -8, +7+9 enhancers in both blood and endothelial cells. By contrast Pu.1, an Ets factor specific to the blood lineage, and Gata2 binding was only detected in blood. Gata2 was bound only at +7 and GATA motifs were required for hematopoietic activity. This modular assembly of regulators gives blood and endothelial cells the regulatory freedom to independently fine-tune gene expression and emphasizes the role of regulatory divergence in driving functional divergence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.