ReviewHuman reproduction update
Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
Review in Human reproduction update. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 105 citations in OpenAlex.
- Genetic and Epigenetic Components in the Pathogenesis of Adenomyosis and Endometriosis in Adolescents.Biomedicines · 2025Review
- NOD1, NOD2, PYDC1, and PYDC2 gene polymorphisms in ovarian endometriosis.Frontiers in medicine · 2024Article
- Implication of FSHB rs10835638 variant in endometriosis in Brazilian women.Einstein (Sao Paulo, Brazil) · 2023Article
- Polymorphisms of TNF-alpha (- 308), IL-1beta (+ 3954) and IL1-Ra (VNTR) are associated to severe stage of endometriosis in Mexican women: a case control study.BMC women's health · 2022Article
- Association of Polymorphisms in Antioxidant Enzyme-Encoding Genes with Diabetic Nephropathy in a Group of Saudi Arabian Patients with Type II Diabetes Mellitus.International journal of general medicine · 2022Article
- DNMT1 and DNMT3B gene variants and their association with endometriosis in South Indian women.Molecular biology reports · 2022Article
- Genetic polymorphism of lysyl oxidase, glutathione S-transferase M1, glutathione-S-transferase T1, and glutathione S-transferase P1 genes as risk factors for lung cancer in Egyptian patients.Molecular biology reports · 2021Article
- Defining the genetic profile of endometriosis.Experimental and therapeutic medicine · 2019Review
- The Association between TNF-alpha Gene Polymorphisms and Endometriosis in An Iranian Population.International journal of fertility & sterility · 2019Article
- Interaction with angiotensin-converting enzyme-encoding gene in female infertility: Insertion and deletion polymorphism studies.Saudi journal of biological sciences · 2018Article
- A higher prevalence of endometriosis among Asian women does not contribute to poorer IVF outcomes.Journal of assisted reproduction and genetics · 2017Article
- Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population.International journal of reproductive biomedicine · 2016Article
- Glutathione S-transferase M1 and T1 gene polymorphisms in Brazilian women with endometriosis.Journal of assisted reproduction and genetics · 2015Article
- LH (Trp8Arg/Ile15Thr), LHR (insLQ) and FSHR (Asn680Ser) polymorphisms genotypic prevalence in women with endometriosis and infertility.Journal of assisted reproduction and genetics · 2015Article
- BRCA1 alterations are associated with endometriosis, but BRCA2 alterations show no detectable endometriosis risk: a study in Indian population.Journal of assisted reproduction and genetics · 2015Article
- Article
- Endometriosis and ovarian cancer.World journal of clinical oncology · 2014Article
- Endometriosis still a challenge.Journal of medicine and life · 2014Review
- Women with endometriosis have a higher DNA repair capacity and diminished breast cancer risk.Molecular cancer biology · 2013Article
- Nitric oxide modulates mitochondrial activity and apoptosis through protein S-nitrosylation for preimplantation embryo development.Journal of assisted reproduction and genetics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometriosis has a strong genetic component, and numerous genetic studies have been reported.
methodsWe have systematically reviewed these studies and included 114 in our final selection.
resultsWe found no consistent evidence linking endometriosis with specific polymorphisms in genes encoding inflammatory mediators, proteins involved in sex steroid metabolism, vascular function and tissue remodelling. Although a number of polymorphisms have been associated with endometriosis in selected populations, the associations have not been independently confirmed, either because only single studies were carried out on these markers/genes or because other studies reported no association. The most solid evidence linking specific polymorphisms to endometriosis came from studies investigating glutathione-S-transferase, a phase II detoxification enzyme. Carriage of the GSTT1 null deletion variant showed consistent association with endometriosis with a 29% increased risk; however, it cannot be excluded that this result was due to publication bias, and this association should be independently confirmed in large-scale, well-designed case-control studies.
conclusionsThe evidence of an association between genetic polymorphisms and endometriosis is weak. Carriage of the GSTT1 null deletion may moderately increase the risk of this disease. We suggest that the methodology of association studies should be improved in order to identify and validate associations in endometriosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.