ArticleBiophysical journal2008
Slow stress propagation in adherent cells.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients.eLife · 2026Article
- Targeting cell-matrix interface mechanobiology by integrating AFM with fluorescence microscopy.Progress in biophysics and molecular biology · 2022Review
- Poroelastic osmoregulation of living cell volume.iScience · 2021Article
- Article
- Anisotropy vs isotropy in living cell indentation with AFM.Scientific reports · 2019Article
- Mapping heterogeneity of cellular mechanics by multi-harmonic atomic force microscopy.Nature protocols · 2018Article
- Size- and speed-dependent mechanical behavior in living mammalian cytoplasm.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells.Biomaterials · 2015Article
- Nanobiomechanics of living cells: a review.Interface focus · 2014Review
- Mechanical fluidity of fully suspended biological cells.Biophysical journal · 2013Article
- A multi-structural single cell model of force-induced interactions of cytoskeletal components.Biomaterials · 2013Article
- The cytoplasm of living cells behaves as a poroelastic material.Nature materials · 2013Article
- The biomechanical integrin.Journal of biomechanics · 2010Review
- Mechanics of the F-actin cytoskeleton.Journal of biomechanics · 2010Review
- Animal cell hydraulics.Journal of cell science · 2009Article
- Extracellular matrix stiffness and architecture govern intracellular rheology in cancer.Biophysical journal · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Mechanical cues influence a wide range of cellular behaviors including motility, differentiation, and tumorigenesis. Although previous studies elucidated the role of specific players such as ion channels and focal adhesions as local mechanosensors, the investigation of how mechanical perturbations propagate across the cell is necessary to understand the spatial coordination of cellular processes. Here we quantify the magnitude and timing of intracellular stress propagation, using atomic force microscopy and particle tracking by defocused fluorescence microscopy. The apical cell surface is locally perturbed by atomic force microscopy cantilever indentation, and distal displacements are measured in three dimensions by tracking integrin-bound fluorescent particles. We observe an immediate response and slower equilibration, occurring over times that increase with distance from perturbation. This distance-dependent equilibration occurs over several seconds and can be eliminated by disruption of the actin cytoskeleton. Our experimental results are not explained by traditional viscoelastic models of cell mechanics, but they are consistent with predictions from poroelastic models that include both cytoskeletal deformation and flow of the cytoplasm. Our combined atomic force microscopy-particle tracking measurements provide direct evidence of slow, distance-dependent dissipative stress propagation in response to external mechanical cues and offer new insights into mechanical models and physiological behaviors of adherent cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.