ArticleBiophysical journal2008
Probing the lipid membrane dipole potential by atomic force microscopy.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Alteration of Lipid Bilayer Electrical Potential by Phytochemicals and Synthetic Analogs: Implications for Cellular Function.Biomolecules · 2026Review
- Water flipping and the oxygen evolution reaction on FeNature communications · 2025Article
- Look Beyond Plasma Membrane Biophysics: Revealing Considerable Variability of the Dipole Potential Between Plasma and Organelle Membranes of Living Cells.International journal of molecular sciences · 2025Article
- Advances in using ultrasound to regulate the nervous system.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Bridging molecular-scale interfacial science with continuum-scale models.Nature communications · 2024Review
- Local pH at Nonionic and Zwitterionic Lipid/Water Interfaces Revealed by Heterodyne-Detected Electronic Sum-Frequency Generation: A Unified View to Predict Interfacial pH of Biomembranes.The journal of physical chemistry. B · 2023Article
- Review
- A physical perspective to understand myelin II: The physical origin of myelin development.Frontiers in neuroscience · 2022Article
- An ω-3, but Not an ω-6 Polyunsaturated Fatty Acid Decreases Membrane Dipole Potential and Stimulates Endo-Lysosomal Escape of Penetratin.Frontiers in cell and developmental biology · 2021Article
- Saturation of charge-induced water alignment at model membrane surfaces.Science advances · 2018Article
- Assessing anesthetic activity through modulation of the membrane dipole potential.Journal of lipid research · 2017Article
- The dipole potential correlates with lipid raft markers in the plasma membrane of living cells.Journal of lipid research · 2017Article
- Direct Measurement of the Effect of Cholesterol and 6-Ketocholestanol on the Membrane Dipole Electric Field Using Vibrational Stark Effect Spectroscopy Coupled with Molecular Dynamics Simulations.The journal of physical chemistry. B · 2017Article
- Measurement of the membrane dipole electric field in DMPC vesicles using vibrational shifts of p-cyanophenylalanine and molecular dynamics simulations.The journal of physical chemistry. B · 2015Article
- Nanoscale measurement of the dielectric constant of supported lipid bilayers in aqueous solutions with electrostatic force microscopy.Biophysical journal · 2013Article
- Charge equilibration force fields for molecular dynamics simulations of lipids, bilayers, and integral membrane protein systems.Biochimica et biophysica acta · 2012Review
- Molecular dynamics simulation of hydrated DPPC monolayers using charge equilibration force fields.Journal of computational chemistry · 2012Article
- Physical determinants of β-barrel membrane protein folding in lipid vesicles.Biophysical journal · 2011Article
- Article
- Transmembrane potential measurements on plant cells using the voltage-sensitive dye ANNINE-6.Protoplasma · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The electrostatic properties of biological membranes can be described by three parameters: the transmembrane potential, the membrane surface potential, and the membrane dipole potential. The first two are well characterized in terms of their magnitudes and biological effects. The dipole potential, however, is not well characterized. Various methods to measure the membrane dipole potential indirectly yield different values, and there is not even agreement on the source of the membrane dipole moment. This ambiguity impedes investigations into the biological effects of the membrane dipole moment, which should be substantial considering the large interfacial fields with which it is associated. Electrostatic analysis of phosphatidylcholine lipid membranes with the atomic force microscope reveals a repulsive force between the negatively charged probe tips and the zwitterionic lipids. This unexpected interaction has been analyzed quantitatively to reveal that the repulsion is due to a weak external field created by the internal membrane dipole potential. The analysis yields a dipole moment of 1.5 Debye per lipid with a dipole potential of +275 mV for supported phosphatidylcholine membranes. This new ability to quantitatively measure the membrane dipole moment in a noninvasive manner with nanometer scale spatial resolution will be useful in identifying the biological effects of the dipole potential.
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