Evidence map›Paper›PMID 18805392›Full record

ReviewBiochimica et biophysica acta2009

Phase diagrams and lipid domains in multicomponent lipid bilayer mixtures.

Gerald W Feigenson

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Toxic Effects of Butanol in the Plane of the Cell Membrane.Langmuir : the ACS journal of surfaces and colloids · 2025
    Article
  9. Sorting of complex sphingolipids within the cellular endomembrane systems.Frontiers in cell and developmental biology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Closed-loop fluid-fluid immiscibility in binary lipid-sterol membranes.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. CHARMM-GUIJournal of chemical theory and computation · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Gerald W FeigensonField of Biophysics, Cornell University, Ithaca, NY 14853, USA. gwf3@cornell.edu

Funding

Membrane Control of Protein-Protein Contact. Simulation Based on Phase DiagramsR01GM077198 · NIGMS · CORNELL UNIVERSITY · PI FEIGENSON, GERALD WILLIAM · 2007 to 2010
$1.6M
NIGMS NIH HHS R01 GM077198
6 · The paper itself

Abstract

Understanding the phase behavior of biological membranes is helped by the study of more simple systems. Model membranes that have as few as 3 components exhibit complex phase behavior that can be well described, providing insight for biological membranes. A number of different studies are in agreement on general findings for some compositional phase diagrams, in particular, those that model the outer leaflet of animal cell plasma membranes. These model mixtures include cholesterol, together with one high-melting lipid and one low-melting lipid. An interesting finding is of two categories of such 3-component mixtures, leading to what we term Type I and Type II compositional phase diagrams. The latter have phase regions of macroscopic coexisting domains of [Lalpha+Lbeta+Lo] and of [Lalpha+Lo], with domains resolved under the light microscope. Type I mixtures have the same phase coexistence regions, but the domains seem to be nanoscopic. Type I mixtures are likely to be better models for biological membranes.

Indexed as

Models, TheoreticalAnimalsHydrophobic and Hydrophilic InteractionsLipid BilayersMembrane LipidsMembrane MicrodomainsMembranesModels, BiologicalSurface PropertiesLipid BilayersMembrane Lipids

Identifiers

PMID18805392
PMCPMC2637376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.