ReviewLancet (London, England)2008
Early identification of atopy in the prediction of persistent asthma in children.
Review in Lancet (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02541331 (Influence of Polyvalent Mechanical Bacterial Lysate ISMIGEN® on Clinical Course of Asthma and Related Immunological Parameters in Asthmatic Children), which is not on this map. Cited by 145 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Polyvalent Mechanical Bacterial Lysate ISMIGEN® on Clinical Course of Asthma and Related Immunological Parameters in Asthmatic Children (EOLIA Study): Randomised Double-blind Placebo-controlled Multicentre Parallel-group Study
Who cites it
145 citing papers in PubMed, 3 syntheses or guidelines pooled it, 344 citations in OpenAlex.
- A systematic review of predictive models for asthma development in children.BMC medical informatics and decision making · 2015Pooled it
- Glucocorticoids for acute viral bronchiolitis in infants and young children.The Cochrane database of systematic reviews · 2013Pooled it
- Epinephrine for bronchiolitis.The Cochrane database of systematic reviews · 2011Pooled it
- Non-atopic rhinitis at age 6 is associated with subsequent development of asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Fear of repeated injections in children younger than 4 years receiving subcutaneous allergy immunotherapy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2012Trial
- Review
- Early-Life Allergen Sensitization Phenotypes and Exploratory Machine-Learning Interpretation of School-Age Asthma Risk.Journal of asthma and allergy · 2026Article
- Assessment of Bronchodilator Responsiveness and Spirometric Patterns in Patients with Rhinitis and Suspected Asthma.Journal of asthma and allergy · 2026Article
- Carbamylated monomeric allergoids for sublingual immunotherapy in pediatric respiratory allergies.Asia Pacific allergy · 2025Review
- Catalase-encapsulated matrix metalloproteinase-9 responsive nanogels for modulation of inflammatory response and treatment of neutrophilic asthma.Journal of nanobiotechnology · 2025Article
- Use of antibiotics in early life and development of diseases in childhood: nationwide registry study.BMJ medicine · 2025Article
- Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity.Journal of asthma and allergy · 2025Article
- Association of urinary eosinophilic protein X at age 3 years and subsequent persistence of wheezing and asthma diagnosis in adolescence.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Impact of wheat sensitization on wheeze and T2 phenotypes in general population of children.The journal of allergy and clinical immunology. Global · 2024Article
- Diversity under a Microscope: As Biodiversity Diminishes, Do Allergies and Asthma Increase?Environmental health perspectives · 2024Article
- Biomarkers in allergen immunotherapy: Focus on eosinophilic inflammation.Asia Pacific allergy · 2024Review
- Predictive Value of Impulse Oscillometry Combined with Fractional Expiratory Nitric Oxide Test for Asthma in Preschool Children.Journal of asthma and allergy · 2024Article
- Comparison of 16S rRNA gene sequencing microbiota among children with serological IgE-mediated food hypersensitivity.Pediatric research · 2024Article
- Clinical Predictors of Severe Exacerbations in Pediatric Patients With Recurrent Wheezing.Cureus · 2024Article
- Association of rhinovirus and potentially pathogenic bacterial detections in the first 3 months of life with subsequent wheezing in childhood.Pediatric pulmonology · 2023Article
85 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 13 institutions in 9 countries.
Funding
Abstract
The long-term solution to the asthma epidemic is thought to be prevention, and not treatment of established disease. Atopic asthma arises from gene-environment interactions, which mainly take place during a short period in prenatal and postnatal development. These interactions are not completely understood, and hence primary prevention remains an elusive goal. We argue that primary-care physicians, paediatricians, and specialists lack knowledge of the role of atopy in early life in the development of persistent asthma in children. In this review, we discuss how early identification of children at high risk is feasible on the basis of available technology and important for potential benefits to the children. Identification of an asthmatic child's atopic status in early life has practical clinical and prognostic implications, and sets the basis for future preventative strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.