Evidence map›Paper›PMID 18805174›Full record

ArticleThe Annals of thoracic surgery2008

Targeted myocardial microinjections of a biocomposite material reduces infarct expansion in pigs.

Rupak Mukherjee, Juozas A Zavadzkas, Stuart M Saunders, Julie E McLean, Laura B Jeffords, Christy Beck, Robert E Stroud, Allyson M Leone, Christine N Koval, William T Rivers and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Annals of thoracic surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 107 citations in OpenAlex.

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  10. Engineered biomaterials for heart disease.Current opinion in biotechnology · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Rupak MukherjeeDivision of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina 29425, USA. mukherr@musc.edu
Juozas A Zavadzkas
Stuart M Saunders
Julie E McLean
Laura B Jeffords
Christy Beck
Robert E Stroud
Allyson M Leone
Christine N Koval
William T Rivers
Shubhayu Basu
Alexander Sheehy
Gene Michal
Francis G Spinale
Medical University of South Carolina · USAbbott Vascular (United States)Abbott (United States) · US

Funding

TRANSLATIONAL REGULATION OF CARDIAC PROTEIN SYNTHESISP01HL048788 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI COOPER, GEORGE · 1993 to 2007
$15.9M
Vitamin D Status in Pulmonary FibrosisR03HL097012 · NHLBI · UNIVERSITY OF LOUISVILLE · PI RAMIREZ, ALLAN · 2009 to 2010
$155k
STRUCTURAL REMODELING IN CARDIOMYOPATHY AND RECOVERYR29HL045024 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SPINALE, FRANCIS G · 1991 to 1995
–
NHLBI NIH HHS HL-45024NHLBI NIH HHS HL-97012NHLBI NIH HHS P01 HL048788NHLBI NIH HHS R03 HL097012PHS HHS P01-48788
6 · The paper itself

Abstract

backgroundLeft ventricular (LV) remodeling after myocardial infarction (MI) commonly causes infarct expansion (IE). This study sought to interrupt IE through microinjections of a biocompatible composite material into the post-MI myocardium.

methodsMI was created in 21 pigs (coronary ligation). Radiopaque markers (2-mm diameter) were placed for IE (fluoroscopy). Pigs were randomized for microinjections (25 injections; 2- x 2-cm array; 200 microL/injection) at 7 days post-MI of a fibrin-alginate composite (Fib-Alg; fibrinogen, fibronectin, factor XIII, gelatin-grafted alginate, thrombin; n = 11) or saline (n = 10).

resultsAt 7 days after injection (14 days post-MI), LV posterior wall thickness was higher in the Fib-Alg group than in the saline group (1.07 +/- 0.11 vs 0.69 +/- 0.07 cm, respectively, p = 0.002). At 28 days post-MI, the area within the markers (IE) increased from baseline (1 cm2) in the saline (1.71 +/- 0.13 cm2, p = 0.010) and Fib-Alg groups (1.44 +/- 0.23 cm2, p < 0.001). However, the change in IE at 21 and 28 days post-MI was reduced in the Fib-Alg group (p=0.043 and p=0.019). Total collagen content within the MI region was similar in the saline and Fib-Alg groups (12.8 +/- 1.7 and 11.6 +/- 1.5 microg/mg, respectively, p = NS). However, extractable collagen, indicative of solubility, was lower in the Fib-Alg group than the saline group (59.1 +/- 3.5 vs 71.0 +/- 6.1 microg/mL, p = 0.020).

conclusionsTargeted myocardial microinjection of the biocomposite attenuated the post-MI decrease in LV wall thickness and infarct expansion. Thus, intraoperative microinjections of biocompatible material may provide a novel approach for interrupting post-MI LV remodeling.

Indexed as

Ventricular RemodelingAnimalsBiocompatible MaterialsDisease Models, AnimalFemaleInjections, IntralesionalMaleMicroinjectionsMyocardial InfarctionProbabilityRandom AllocationReference ValuesSensitivity and SpecificitySwineBiocompatible Materials

Identifiers

PMID18805174
PMCPMC2664621
OpenAlexW2011272967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.