ArticleDevelopmental biology2008
Wnt6 signaling regulates heart muscle development during organogenesis.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- The pericardium forms as a distinct structure during heart formation.Nature communications · 2025Article
- Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development.PLoS pathogens · 2025Article
- Emerging roles and biomarker potential of WNT6 in human cancers.Cell communication and signaling : CCS · 2024Review
- Wnt signaling in cardiac development and heart diseases.In vitro cellular & developmental biology. Animal · 2024Review
- FOXK1 regulates Wnt signalling to promote cardiogenesis.Cardiovascular research · 2023Article
- Positive feedback regulation ofeLife · 2022Article
- Article
- The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis.Developmental biology · 2019Article
- Article
- Non-canonical WNT6/WNT10A signal factor expression in EBV+ post-transplant smooth muscle tumors.Clinical sarcoma research · 2018Article
- Frizzled-7 is required forBiology open · 2017Article
- Wnt6 influences the viability of mouse embryonic palatal mesenchymal cells via the β-catenin pathway.Experimental and therapeutic medicine · 2017Article
- Conserved signaling mechanisms in Drosophila heart development.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Review
- Correlation study of DNA methylation of WNT6 gene with osteosarcoma in children.Oncology letters · 2017Article
- Distinctive Roles of Canonical and Noncanonical Wnt Signaling in Human Embryonic Cardiomyocyte Development.Stem cell reports · 2016Article
- The Wnt Blows: On the Functional Role of Wnt Signaling inFrontiers in immunology · 2016Review
- Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart.Cardiovascular research · 2015Article
- Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways.Journal of molecular and cellular cardiology · 2015Article
- Wnt6 is required for maxillary palp formation in Drosophila.BMC biology · 2013Article
- Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling.Development (Cambridge, England) · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mesodermal tissue with heart forming potential (cardiogenic mesoderm) is induced during gastrulation. This cardiogenic mesoderm later differentiates into heart muscle tissue (myocardium) and non-muscular heart tissue. Inhibition of Wnt/beta-catenin signaling is known to be required early for induction of cardiogenic mesoderm; however, the identity of the inhibiting Wnt signal itself is still elusive. We have identified Wnt6 in Xenopus as an endogenous Wnt signal, which is expressed in tissues close to and later inside the developing heart. Our loss-of-function experiments show that Wnt6 function is required in the embryo to prevent development of an abnormally large heart muscle. We find, however, that Wnt6 is not required as expected during gastrulation stages, but later during organogenesis stages just before cells of the cardiogenic mesoderm begin to differentiate into heart muscle (myocardium). Our gain-of-function experiments show that Wnt6 and also activated canonical Wnt/beta-catenin signaling are capable of restricting heart muscle development at these relatively late stages of development. This repressive role of Wnt signaling is mediated initially via repression of cardiogenic transcription factors, since reinstatement of GATA function can rescue expression of other cardiogenic transcription factors and downstream cardiomyogenic differentiation genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.