ArticleDevelopmental cell2008
The cyclin-dependent kinase Cdk1 directly regulates vacuole inheritance.
Article in Developmental cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Cargo adaptors use a handhold mechanism to engage with myosin V for organelle transport.The Journal of cell biology · 2025Article
- Characterization of a high-intensity band that cross-reacts with FLAG-M2 antibodies in immunoblots in a subset of laboratory strains of Saccharomyces cerevisiae.bioRxiv : the preprint server for biology · 2025Article
- Metabolomics and machine learning approaches for diagnostic biomarkers screening in systemic light chain amyloidosis.Annals of hematology · 2025Article
- Spatiotemporal regulation of organelle transport by spindle position checkpoint kinase Kin4.Journal of cell science · 2024Article
- Review
- Let it go: mechanisms that detach myosin V from the yeast vacuole.Current genetics · 2021Review
- A preferred sequence for organelle inheritance during polarized cell growth.Journal of cell science · 2021Article
- Regulation of the early stages of endoplasmic reticulum inheritance during ER stress.Molecular biology of the cell · 2021Article
- Roles and regulation of myosin V interaction with cargo.Advances in biological regulation · 2021Review
- Cargo Release from Myosin V Requires the Convergence of Parallel Pathways that Phosphorylate and Ubiquitylate the Cargo Adaptor.Current biology : CB · 2020Article
- Spatial regulation of organelle release from myosin V transport by p21-activated kinases.The Journal of cell biology · 2017Article
- Article
- Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning.Molecular biology of the cell · 2015Article
- Casein kinase 1 promotes initiation of clathrin-mediated endocytosis.Developmental cell · 2015Article
- Breaking up isn't easy: myosin V and its cargoes need Dma1 ubiquitin ligase's help.Developmental cell · 2014Article
- Release from myosin V via regulated recruitment of an E3 ubiquitin ligase controls organelle localization.Developmental cell · 2014Article
- Mitotic phosphorylation of Exo84 disrupts exocyst assembly and arrests cell growth.The Journal of cell biology · 2013Article
- Mitochondrial association, protein phosphorylation, and degradation regulate the availability of the active Rab GTPase Ypt11 for mitochondrial inheritance.Molecular biology of the cell · 2013Article
- Overlap of cargo binding sites on myosin V coordinates the inheritance of diverse cargoes.The Journal of cell biology · 2012Article
- Analysis of yeast endocytic site formation and maturation through a regulatory transition point.Molecular biology of the cell · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In budding yeast, vacuole inheritance is tightly coordinated with the cell cycle. The movement of vacuoles and several other organelles is actin-based and is mediated by interaction between the yeast myosin V motor Myo2 and organelle-specific adaptors. Myo2 binds to vacuoles via the adaptor protein Vac17, which binds to the vacuole membrane protein Vac8. Here we show that the yeast cyclin-dependent kinase Cdk1 phosphorylates Vac17 and that phosphorylation of Vac17 parallels cell cycle-dependent movement of the vacuole. Substitution of the Cdk1 sites in Vac17 decreases its interaction with Myo2 and causes a partial defect in vacuole inheritance. This defect is enhanced in the presence of Myo2 with mutated phosphorylation sites. Thus, Cdk1 appears to control the timing of vacuole movement. The presence of multiple predicted Cdk1 sites in other organelle-specific myosin V adaptors suggests that the inheritance of other cytoplasmic organelles may be regulated by a similar mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.