ArticleBiomaterials2008
Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1).
Article in Biomaterials, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
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- Evaluating Angiogenic Potential of Small Molecules Using Genetic Network Approaches.Regenerative engineering and translational medicine · 2019Article
- Arteriogenesis in murine adipose tissue is contingent on CD68Microcirculation (New York, N.Y. : 1994) · 2017Article
- Dorsal skinfold chamber models in mice.GMS Interdisciplinary plastic and reconstructive surgery DGPW · 2017Article
- Depot-Based Delivery Systems for Pro-Angiogenic Peptides: A Review.Frontiers in bioengineering and biotechnology · 2015Review
- Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning.Acta biomaterialia · 2014Article
- Endothelialized biomaterials for tissue engineering applications in vivo.Trends in biotechnology · 2011Review
- Harnessing systems biology approaches to engineer functional microvascular networks.Tissue engineering. Part B, Reviews · 2010Review
- Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells.Biotechnology and bioengineering · 2009Article
- Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecule.Bioinformatics (Oxford, England) · 2008Article
- Engineering vascularized tissues using natural and synthetic small molecules.Organogenesis · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Phthalimide neovascular factor (PNF1, formerly SC-3-149) is a potent stimulator of proangiogenic signaling pathways in endothelial cells. In this study, we evaluated the in vivo effects of sustained PNF1 release to promote ingrowth and expansion of microvascular networks surrounding biomaterial implants. The dorsal skinfold window chamber was used to evaluate the structural remodeling response of the local microvasculature. PNF1 was released from poly(lactic-co-glycolic acid) (PLAGA) films, and a transport model was utilized to predict PNF1 penetration into the surrounding tissue. PNF1 significantly expanded microvascular networks within a 2mm radius from implants after 3 and 7 days by increasing microvessel length density and lumenal diameter of local arterioles and venules. Staining of histological sections with CD11b showed enhanced recruitment of circulating white blood cells, including monocytes, which are critical for the process of vessel enlargement through arteriogenesis. As PNF1 has been shown to modulate MT1-MMP, a facilitator of CCL2 dependent leukocyte transmigration, aspects of window chamber experiments were repeated in CCR2(-/-) (CCL2 receptor) mouse chimeras to more fully explore the critical nature of monocyte recruitment on the therapeutic benefits of PNF1 function in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.