ArticleMutation research2008
Particulate matter inhibits DNA repair and enhances mutagenesis.
Article in Mutation research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Mapping three decades of air pollution-lung cancer research: trends, hotspots, and networks (1990-2025).Frontiers in oncology · 2025Pooled it
- The impact of particulate matter 2.5 on the risk of hepatocellular carcinoma: a meta-analysis.International archives of occupational and environmental health · 2022Pooled it
- Impact of particulate matter 2.5 on a mouse model of lung adenocarcinoma.BMC pulmonary medicine · 2026Article
- Molecular mechanisms of air pollution-induced carcinogenesis and the emerging role of microplastics.Human genomics · 2025Review
- Airborne PMInternational journal of molecular sciences · 2025Article
- BKScientific reports · 2025Article
- Circular RNA circ_0004470 accelerates the occurrence of lung cancer by promoting DNA damage and cell cycle arrest.The Journal of biological chemistry · 2025Article
- Association of Maternal Exposure to Fine Particulate Matter During Pregnancy with Anterior Segment Dysgenesis Risk: A Matched Case-Control Study.Journal of clinical medicine · 2025Article
- Intra-Continental Transport of Western Wildfire Smoke Heightens Health Risks Across North America.International journal of environmental research and public health · 2025Article
- The role of PM2.5 exposure in lung cancer: mechanisms, genetic factors, and clinical implications.EMBO molecular medicine · 2025Review
- An Insight on Microfluidic Organ-on-a-Chip Models for PMACS omega · 2024Review
- Air pollutants and primary liver cancer mortality: a cohort study in crop-burning activities and forest fires area.Frontiers in public health · 2024Article
- Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns.Molecular psychiatry · 2023Article
- Scanning ion conductance microscopy reveals differential effect of PMAnalytical and bioanalytical chemistry · 2023Article
- Short-term effects of high-resolution (1-km) ambient PMFrontiers in public health · 2023Article
- Exposure to Air Pollution and Survival in Follow-Up after Hepatocellular Carcinoma.Liver cancer · 2022Article
- Air Pollution, Socioeconomic Status, and Age-Specific Mortality Risk in the United States.JAMA network open · 2022Article
- MicroRNAs: Potential mediators between particulate matter 2.5 and Th17/Treg immune disorder in primary membranous nephropathy.Frontiers in pharmacology · 2022Article
- Ecosystem services and impact of industrial pollution on urban health: evidence from Durgapur, West Bengal, India.Environmental monitoring and assessment · 2021Review
- Potential cytotoxicity of trace elements and polycyclic aromatic hydrocarbons bounded to particulate matter: a review on in vitro studies on human lung epithelial cells.Environmental science and pollution research international · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to ambient air pollution has been associated with adverse health effects including lung cancer. A recent epidemiology study has established that each 10 microg/m3 elevation in long-term exposure to average PM2.5 ambient concentration was associated with approximately 8% of lung cancer mortality. The underlying mechanisms of how PM contributes to lung carcinogenesis, however, remain to be elucidated. We have recently found that transition metals such as nickel and chromium and oxidative stress induced lipid peroxidation metabolites such as aldehydes can greatly inhibit nucleotide excision repair (NER) and enhance carcinogen-induced mutations. Because PM is rich in metal and aldehyde content and can induce oxidative stress, we tested the effect of PM on DNA repair capacity in cultured human lung cells using in vitro DNA repair synthesis and host cell reactivation assays. We found that PM greatly inhibits NER for ultraviolet (UV) light and benzo(a)pyrene diol epoxide (BPDE) induced DNA damage in human lung cells. We further demonstrated that PM exposure can significantly increase both spontaneous and UV-induced mutagenesis. These results together suggest that the carcinogenicity of PM may act through its combined effect on suppression of DNA repair and enhancement of DNA replication errors.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.