ReviewCurrent opinion in biotechnology2008
Tweaking biological switches through a better understanding of bistability behavior.
Review in Current opinion in biotechnology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- The dynamics of prion spreading is governed by the interplay between the non-linearities of tissue response and replication kinetics.iScience · 2024Article
- Compartmental exchange regulates steady states and stochastic switching of a phosphorylation network.Biophysical journal · 2024Article
- Modeling ATP-mediated endothelial cell elongation on line patterns.Biomechanics and modeling in mechanobiology · 2022Article
- Predicting Functional Connectivity From Observed and Latent Structural ConnectivityFrontiers in neuroscience · 2022Article
- Article
- The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia.Frontiers in neuroscience · 2021Article
- A Stronger Transcription Regulatory Circuit of HIV-1C Drives the Rapid Establishment of Latency with Implications for the Direct Involvement of Tat.Journal of virology · 2020Article
- A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src.Cell reports · 2018Article
- Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model.BMC systems biology · 2017Article
- An innovative platform for quick and flexible joining of assorted DNA fragments.Scientific reports · 2016Article
- Modified lactic acid bacteria detect and inhibit multiresistant enterococci.ACS synthetic biology · 2015Article
- Cis-Antisense Transcription Gives Rise to Tunable Genetic Switch Behavior: A Mathematical Modeling Approach.PloS one · 2015Article
- Functional characteristics of a double negative feedback loop mediated by microRNAs.Cognitive neurodynamics · 2013Article
- Toggle switch: noise determines the winning gene.Physical biology · 2013Article
- Integration-dependent bacteriophage immunity provides insights into the evolution of genetic switches.Molecular cell · 2013Article
- Type of noise defines global attractors in bistable molecular regulatory systems.Journal of theoretical biology · 2013Article
- Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness.PLoS genetics · 2013Article
- A nonlinear dynamical theory of cell injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Article
- SlrA/SinR/SlrR inhibits motility gene expression upstream of a hypersensitive and hysteretic switch at the level of σ(D) in Bacillus subtilis.Molecular microbiology · 2012Article
- B cell activation triggered by the formation of the small receptor cluster: a computational study.PLoS computational biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Many biological events are binary. The switch between mutually exclusive OFF to ON state in response to a stimulus is frequently mediated by a control circuit with a positive and/or a negative feedback. Such a system typically exhibits hysteresis with its switching ON and OFF stimulus levels dependent on the current state of the system. The system can be shown to be bistable both experimentally and mathematically. Work to synthesize such switches by combining natural or engineered components has begun to illustrate the potential of such control circuits in many areas of applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.