ReviewMolecular brain2008
Transcriptional regulation of long-term memory in the marine snail Aplysia.
Review in Molecular brain, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 87 citations in OpenAlex.
- A repressive regulatory cascade shapes temporal patterning of activity-regulated gene expression in a defined sensory neuron type.bioRxiv : the preprint server for biology · 2026Article
- Minding the gap between artificial and biological computing paradigms for biologically loyal AI.Frontiers in systems neuroscience · 2025Article
- Long-term anti-predator learning and memory differ across populations and sexes in an intertidal snail.Proceedings. Biological sciences · 2024Article
- Single-neuron analysis of aging-associated changes in learning reveals impairments in transcriptional plasticity.Aging cell · 2024Article
- Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and behavioral plasticity.Current biology : CB · 2023Article
- Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and behavioral plasticity.bioRxiv : the preprint server for biology · 2023Article
- An age-related decline in the cholinergic synaptic response may cause the firing pattern in the jaw-closing motor neurons, which resembles the aversive taste response in the feeding behavior of old Aplysia kurodai.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice.Molecular brain · 2021Article
- Short-term memory reactivation of a weak CS-US association promotes long-term memory persistence in conditioned odor aversion.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Environmental Light Is Required for Maintenance of Long-Term Memory inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Learning and aging affect neuronal excitability and learning.Neurobiology of learning and memory · 2020Review
- Balanced actions of protein synthesis and degradation in memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Superior long-term synaptic memory induced by combining dual pharmacological activation of PKA and ERK with an enhanced training protocol.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Article
- Effects of aging on the food intake in the feeding behavior of Aplysia kurodai.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- ApCPEB4, a non-prion domain containing homolog of ApCPEB, is involved in the initiation of long-term facilitation.Molecular brain · 2016Article
- Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer's Disease.Neurotoxicity research · 2016Review
- Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation.Molecular & cellular proteomics : MCP · 2016Article
- Phosphodiesterase 4D: an enzyme to remember.British journal of pharmacology · 2015Review
- Accounting for the delay in the transition from acute to chronic pain: axonal and nuclear mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whereas the induction of short-term memory involves only covalent modifications of constitutively expressed preexisting proteins, the formation of long-term memory requires gene expression, new RNA, and new protein synthesis. On the cellular level, transcriptional regulation is thought to be the starting point for a series of molecular steps necessary for both the initiation and maintenance of long-term synaptic facilitation (LTF). The core molecular features of transcriptional regulation involved in the long-term process are evolutionally conserved in Aplysia, Drosophila, and mouse, and indicate that gene regulation by the cyclic AMP response element binding protein (CREB) acting in conjunction with different combinations of transcriptional factors is critical for the expression of many forms of long-term memory. In the marine snail Aplysia, the molecular mechanisms that underlie the storage of long-term memory have been extensively studied in the monosynaptic connections between identified sensory neuron and motor neurons of the gill-withdrawal reflex. One tail shock or one pulse of serotonin (5-HT), a modulatory transmitter released by tail shocks, produces a transient facilitation mediated by the cAMP-dependent protein kinase leading to covalent modifications in the sensory neurons that results in an enhancement of transmitter release and a strengthening of synaptic connections lasting minutes. By contrast, repeated pulses of 5-hydroxytryptamine (5-HT) induce a transcription- and translation-dependent long-term facilitation (LTF) lasting more than 24 h and trigger the activation of a family of transcription factors in the presynaptic sensory neurons including ApCREB1, ApCREB2 and ApC/EBP. In addition, we have recently identified novel transcription factors that modulate the expression of ApC/EBP and also are critically involved in LTF. In this review, we examine the roles of these transcription factors during consolidation of LTF induced by different stimulation paradigms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.