ArticleBMC microbiology2008
Role of IFN-gamma and IL-6 in a protective immune response to Yersinia enterocolitica in mice.
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Flagellin adjuvanted F1/V subunit plague vaccine induces T cell and functional antibody responses with unique gene signatures.NPJ vaccines · 2020Article
- Salmonella Gallinarum delivering M2eCD40L in protein and DNA formats acts as a bivalent vaccine against fowl typhoid and H9N2 infection in chickens.Veterinary research · 2018Article
- Edwardsiella piscicida Type III Secretion System Effector EseK Inhibits Mitogen-Activated Protein Kinase Phosphorylation and Promotes Bacterial Colonization in Zebrafish Larvae.Infection and immunity · 2018Article
- Oral immunization with a novel attenuated Salmonella Typhimurium encoding influenza HA, M2e and NA antigens protects chickens against H7N9 infection.Veterinary research · 2018Article
- A consensus-hemagglutinin-based vaccine delivered by an attenuated Salmonella mutant protects chickens against heterologous H7N1 influenza virus.Oncotarget · 2017Article
- Tissue dual RNA-seq allows fast discovery of infection-specific functions and riboregulators shaping host-pathogen transcriptomes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- An Influenza HA and M2e Based Vaccine Delivered by a Novel AttenuatedFrontiers in microbiology · 2017Article
- Yersinia enterocolitica YopH-Deficient Strain Activates Neutrophil Recruitment to Peyer's Patches and Promotes Clearance of the Virulent Strain.Infection and immunity · 2016Article
- A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.The Journal of experimental medicine · 2012Article
- Cluster analysis of host cytokine responses to biodefense pathogens in a whole blood ex vivo exposure model (WEEM).BMC microbiology · 2012Article
- Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity.The Journal of experimental medicine · 2011Article
- YopJ-promoted cytotoxicity and systemic colonization are associated with high levels of murine interleukin-18, gamma interferon, and neutrophils in a live vaccine model of Yersinia pseudotuberculosis infection.Infection and immunity · 2010Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundYersinia outer protein (Yop) H is a secreted virulence factor of Yersinia enterocolitica (Ye), which inhibits phagocytosis of Ye and contributes to the virulence of Ye in mice. The aim of this study was to address whether and how YopH affects the innate immune response to Ye in mice.
resultsFor this purpose, mice were infected with wild type Ye (pYV+) or a YopH-deficient Ye mutant strain (DeltayopH). CD11b+ cells were isolated from the infected spleen and subjected to gene expression analysis using microarrays. Despite the attenuation of DeltayopH in vivo, by variation of infection doses we were able to achieve conditions that allow comparison of gene expression in pYV+ and DeltayopH infection, using either comparable infection courses or splenic bacterial burden. Gene expression analysis provided evidence that expression levels of several immune response genes, including IFN-gamma and IL-6, are high after pYV+ infection but low after sublethal DeltayopH infection. In line with these findings, infection of IFN-gammaR-/- and IL-6-/- mice with pYV+ or DeltayopH revealed that these cytokines are not necessarily required for control of DeltayopH, but are essential for defense against infection with the more virulent pYV+. Consistently, IFN-gamma pretreatment of bone marrow derived macrophages (BMDM) strongly enhanced their ability in killing intracellular Ye bacteria.
conclusionIn conclusion, this data suggests that IFN-gamma-mediated effector mechanisms can partially compensate virulence exerted by YopH. These results shed new light on the protective role of IFN-gamma in Ye wild type infections.
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