ArticleEvolution & development
Evolution of an insect-specific GROUCHO-interaction motif in the ENGRAILED selector protein.
Article in Evolution & development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 9 citations in OpenAlex.
- Short linear motifs - ex nihilo evolution of protein regulation.Cell communication and signaling : CCS · 2015Review
- Origins of context-dependent gene repression by capicua.PLoS genetics · 2015Article
- Evolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networks.EvoDevo · 2015Review
- Transcription factor networks in Drosophila melanogaster.Cell reports · 2014Article
- Drosophila melanogaster Hox transcription factors access the RNA polymerase II machinery through direct homeodomain binding to a conserved motif of mediator subunit Med19.PLoS genetics · 2014Article
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2 authors at 1 institution in 1 country.
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Abstract
Animal morphology evolves through alterations in the genetic regulatory networks that control development. Regulatory connections are commonly added, subtracted, or modified via mutations in cis-regulatory elements, but several cases are also known where transcription factors have gained or lost activity-modulating peptide motifs. In order to better assess the role of novel transcription factor peptide motifs in evolution, we searched for synapomorphic motifs in the homeotic selectors of Drosophila melanogaster and related insects. Here, we describe an evolutionarily novel GROUCHO (GRO)-interaction motif in the ENGRAILED (EN) selector protein. This "ehIFRPF" motif is not homologous to the previously characterized "engrailed homology 1" (eh1) GRO-interaction motif of EN. This second motif is an insect-specific "WRPW"-type motif that has been maintained by purifying selection in at least the dipteran/lepidopteran lineage. We demonstrate that this motif contributes to in vivo repression of the wingless (wg) target gene and to interaction with GRO in vitro. The acquisition and conservation of this auxiliary peptide motif shows how the number and activity of short peptide motifs can evolve in transcription factors while existing regulatory functions are maintained.
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