ReviewMolecular diagnosis & therapy2008
Biomarkers for Alzheimer disease in cerebrospinal fluid, urine, and blood.
Review in Molecular diagnosis & therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- A New Optical Interferometric Biosensing System Enhanced with Nanoparticles for Alzheimer's Disease in Serum.Biosensors · 2023Article
- Analysis of plasma proteins using 2D gels and novel fluorescent probes: in search of blood based biomarkers for Alzheimer's disease.Proteome science · 2022Article
- Traditional Chinese medicine for anti-Alzheimer's disease: berberine and evodiamine fromChinese medicine · 2020Review
- The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease.Aging cell · 2018Review
- DNA methylation in repetitive elements and Alzheimer disease.Brain, behavior, and immunity · 2011Article
- Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study.Alzheimer's research & therapy · 2011Article
- Current therapies and new strategies for the management of Alzheimer's disease.American journal of Alzheimer's disease and other dementias · 2010Review
- Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.Archives of general psychiatry · 2010Article
- Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old.Molecular cancer · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer disease is the most common cause of dementia, yet its clinical diagnosis remains uncertain until an eventual postmortem histopathology examination. Currently, therapy for patients with Alzheimer disease only treats the symptoms; however, it is anticipated that new disease-modifying drugs will soon become available.Diagnostic tools for detecting Alzheimer disease at an incipient stage that can reliably differentiate the disease from other forms of dementia are of key importance for optimal treatment. Biomarkers have the potential to aid in a correct diagnosis, and great progress has been made in the discovery and development of potentially useful biomarkers in recent years. This includes single protein biomarkers in the cerebrospinal fluid, as well as multi-component biomarkers, and biomarkers based on gene expression. Novel biomarkers that use blood and urine, the more easily available clinical samples, are also being discovered and developed. The plethora of potential biomarkers currently being investigated may soon provide biomarkers that fulfill different functions, not only for diagnostic purposes but also for drug development and to follow disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.