ArticleWorld journal of gastroenterology2008
Metabolic syndrome is associated with erosive esophagitis.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Risk factors and 26-years worldwide prevalence of endoscopic erosive esophagitis from 1997 to 2022: a meta-analysis.Scientific reports · 2023Pooled it
- Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013Pooled it
- Impact of Metabolic Health and Its Changes on Erosive Esophagitis Remission: A Cohort Study.Journal of neurogastroenterology and motility · 2025Article
- Metabolic syndrome is associated with gastroesophageal reflux disease in a large Taiwanese population study.International journal of medical sciences · 2025Article
- Clinical features of gastroesophageal reflux disease and erosive esophagitis: Insights from patients undergoing esophagogastroduodenoscopy in resource-limited Ethiopia.World journal of gastroenterology · 2024Article
- Association between Shift Work and Reflux Esophagitis: The Kangbuk Samsung Health Study.International journal of environmental research and public health · 2021Article
- Differences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- The association between metabolic syndrome and erosive esophagitis: A systematic review and meta-analysis.EXCLI journal · 2021Review
- What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study.BMC gastroenterology · 2019Article
- Weight Loss as a Nonpharmacologic Strategy for Erosive Esophagitis: A 5-Year Follow-up Study.Gut and liver · 2018Article
- Adiponectin level changes among Egyptians with gastroesophageal reflux disease.JGH open : an open access journal of gastroenterology and hepatology · 2018Article
- Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors.Scientific reports · 2017Article
- Article
- Differences in the Insulin Resistance Levels Measured by HOMA-IR between Patients with Erosive and Non-Erosive Gastroesophageal Reflux Disease.Journal of the ASEAN Federation of Endocrine Societies · 2017Article
- Article
- Is Metabolic Syndrome Considered to Be a Risk Factor for Gastroesophageal Reflux Disease (Non-Erosive or Erosive Esophagitis)?: A Systematic Review of the Evidence.Iranian Red Crescent medical journal · 2016Review
- Influence of metabolic syndrome on upper gastrointestinal disease.Clinical journal of gastroenterology · 2016Review
- Metabolic Syndrome and Chronic Laryngitis: The Korean National Health and Nutrition Examination Survey 2008 to 2010.Medicine · 2015Observational
- Subtypes of metabolic syndrome and of other risk factors in Japanese women with erosive esophagitis.Medicine · 2014Article
- Effect of icosapent ethyl (eicosapentaenoic acid ethyl ester) on omeprazole plasma pharmacokinetics in healthy adults.Drugs in R&D · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo clarify whether insulin resistance and metabolic syndrome are risk factors for erosive esophagitis.
methodsA case-control study was performed using the database of the Kangbuk Samsung Hospital Medical Screening Center.
resultsA total of 1679 cases of erosive esophagitis and 3358 randomly selected controls were included. Metabolic syndrome was diagnosed in 21% of the cases and 12% of the controls (P < 0.001). Multiple logistic regressions confirmed the association between erosive esophagitis and metabolic syndrome (Odds ratio, 1.25; 95% CI, 1.04-1.49). Among the components of metabolic syndrome, increased waist circumference, elevated serum triglyceride levels and hypertension were significant risk factors for erosive esophagitis (all P < 0.01). Furthermore, increased insulin resistance (Odds ratio, 0.91; 95% CI, 0.85-0.98) and fatty liver, as diagnosed by ultrasonography (Odds ratio, 1.39; 95% CI, 1.20-1.60), were also related to erosive esophagitis even after adjustment for a series of confounding factors.
conclusionMetabolic syndrome and increased insulin resistance are associated with an increased risk of developing erosive esophagitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.