ArticleGlycoconjugate journal2009
Effect of capsaicin on ligand binding activity of the hippocampal serotonin1A receptor.
Article in Glycoconjugate journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 12 citations in OpenAlex.
- Extramembranous Regions in G Protein-Coupled Receptors: Cinderella in Receptor Biology?The Journal of membrane biology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The serotonin(1A) receptor is an important member of the G-protein coupled receptor family, and is involved in the generation and modulation of a variety of cognitive, behavioral, and developmental functions. In order to examine the role of membrane material properties in ligand binding activity of the hippocampal serotonin(1A) receptor, we monitored the function of the receptor in presence of capsaicin. Capsaicin has been previously shown to increase the elasticity of membrane bilayers. Our results show that the ligand binding activity of the hippocampal serotonin(1A) receptor is reduced in the presence of capsaicin in a linear concentration-dependent manner. This is accompanied by no appreciable change in G-protein coupling of the receptor and overall membrane order. We conclude that material properties of membrane bilayers could play an important role in the function of the serotonin(1A) receptor in particular, and membrane proteins in general.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.